Results 101 to 110 of about 375 (147)

Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

Journal of the American Chemical Society, 2018
We report the first iron-catalyzed difluoromethylation of arylzincs with difluoromethyl 2-pyridyl sulfone via selective C-S bond cleavage. This method employs the readily available, bench-stable fluoroalkyl sulfone reagent and inexpensive iron catalyst, allowing facile access to structurally diverse difluoromethylated arenes at low temperatures.
Wenjun Miao, Yanchuan Zhao, Chuanfa Ni, Bing Gao, Wei Zhang, Jinbo Hu   +5 more
openaire   +2 more sources

Synthesis of difluoromethyl and deuterium-labeled difluoromethyl thioethers from aliphatic electrophiles

Chemical Communications, 2020
A one-pot difluoromethylthiolation of alkyl electrophiles with thiourea and diethyl bromodifluoromethylphosphonate is described. By changing the “H” source to most commonly used “D” source CD 3 OD and D 2 O, this strategy enables efficient synthesis of ...
Tianqi Ding, Lvqi Jiang, Wenbin Yi
openaire   +2 more sources

Copper-Catalyzed Decarboxylative Difluoromethylation

Journal of the American Chemical Society, 2019
We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products ...
Xiaojun Zeng, Wenhao Yan, Samson B. Zacate, Tzu-Hsuan Chao, Xiaodong Sun, Zhi Cao, Kate G. E. Bradford, Matthew Paeth, Sam B. Tyndall, Kundi Yang, Tung-Chun Kuo, Mu-Jeng Cheng, Wei Liu   +12 more
openaire   +2 more sources

A Difluoromethylation Reagent: Access to Difluoromethyl Arenes through Palladium Catalysis

Organic Letters
A new radical difluoromethylation was developed by using inexpensive and readily available difluoroacetic anhydride and N-phenyl-4-methylbenzenesulfonamide for the first time. The reaction of arylboronic acids with the new difluoromethylation reagent, N-phenyl-N-tosyldifluoroacetamide, proceeded smoothly in the presence of palladium catalyst to provide
Xia Chen, Yining Liu, Sheng Zhang, Yang Li, Xiao-Yu Zhou, Xiaoqiang Yu, Xiujuan Feng, Yoshinori Yamamoto, Ming Bao   +8 more
openaire   +2 more sources

Synthesis of Difluoromethyl Thioethers from Difluoromethyl Trimethylsilane and Organothiocyanates Generated In Situ

Angewandte Chemie International Edition, 2015
AbstractA copper‐CF2H complex generated in situ from copper thiocyanate and TMSCF2H smoothly converts organothiocyanates into valuable difluoromethyl thioethers. This reaction step can be combined with several thiocyanation methods to one‐pot protocols, allowing late‐stage difluoromethylthiolations of widely available alkyl halides and arenediazonium ...
Bilguun, Bayarmagnai, Christian, Matheis, Kévin, Jouvin, Lukas J, Goossen   +3 more
openaire   +2 more sources

Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives

Organic Letters
Electron-rich, electron-deficient, and non-activated alkenes can be rapidly functionalized by in situ-generated difluoromethyl nitrile oxide. The (3+2) cycloaddition proceeds at room temperature, has broad functional group tolerance, and can be used for the late-stage modification of bioactive molecules (finasteride and carbamazepine).
Bohdan A. Chalyk, Oleksandr Zginnyk, Andrii V. Khutorianskyi, Pavel K. Mykhailiuk   +3 more
openaire   +2 more sources

Selective difluoromethylation and monofluoromethylation reactions

Chemical Communications, 2009
The selective introduction of fluorine atom(s) and fluorinated moieties into organic molecules has become an important and fast-growing research field, since fluorine atoms play crucial roles in life science and materials science-related applications. Similar to the trifluoromethyl group, both difluoromethyl and monofluoromethyl groups can often bring ...
Jinbo, Hu, Wei, Zhang, Fei, Wang
openaire   +2 more sources

Photocatalytic Hydro Tri/Difluoromethylation of Alkenes with Bench Stable Tri/Difluoromethylating Reagents

Organic Letters, 2023
Herein, we demonstrate the synthesis and characterization of bench stable tri/difluoromethylating reagents and their potential applications in redox neutral hydro tri/difluoromethylation of alkenes enabled by visible light. The new tri/difluoromethylating reagents are obtained on a gram-scale through simply cyclocondensation of commercially available ...
Girish Suresh Yedase, Munaifa Arif, Rositha Kuniyil, Veera Reddy Yatham   +3 more
openaire   +2 more sources

Difluoromethylation of Terminal Alkynes by Fluoroform

Organic Letters, 2015
The difluoromethylation of terminal alkynes through the use of fluoroform as a source of difluorocarbene is described. The choice of solvents and bases was found to be crucial for the transformation. A series of terminal alkynes 1 were nicely converted into the corresponding difluoromethyl alkynes 2 using potassium tert-butoxide in n-decane in moderate
Satoshi, Okusu, Etsuko, Tokunaga, Norio, Shibata   +2 more
openaire   +2 more sources

Visible-Light-Driven Difluoromethylation of Isocyanides with S-(Difluoromethyl)diarylsulfonium Salt: Access to a Wide Variety of Difluoromethylated Phenanthridines and Isoquinolines

The Journal of Organic Chemistry, 2020
A highly efficient approach of visible-light-driven radical difluoromethylation of isocyanides to access a wide variety of difluoromethylated phenanthridines and isoquinolines is herein described. Electrophilic S-(difluoromethyl)diarylsulfonium salt proved to be a good difluoromethyl radical precursor under photoredox catalysis.
Wen-Bing Qin, Wei Xiong, Xin Li, Jia-Yi Chen, Li-Ting Lin, Henry N. C. Wong, Guo-Kai Liu   +6 more
openaire   +2 more sources