Results 81 to 90 of about 836 (184)

Sandmeyer Difluoromethylation of (Hetero-)Arenediazonium Salts

, 2016
A Sandmeyer-type difluoromethylation process has been developed that allows the straightforward conversion of (hetero-)­arenediazonium salts into the corresponding difluoromethyl (hetero-)­arenes under mild conditions.
Lukas J. Goossen (1717156), Christian Matheis (1717159), Kévin Jouvin (1626691)   +2 more
core   +1 more source

Electrochemical-Oxidation-Promoted Direct N-ortho-Selective Difluoromethylation of Heterocyclic N-Oxides

, 2022
An efficient and green electrochemical N-ortho-selective difluoromethylation method of various quinoline and isoquinoline N-oxides has been developed.
Dong Zhang, Kai Guo, Jinlin Cai (9311127), Rongqing Geng, Jinming Yang (366356), Jinze Du, Rongqing Geng (408256), Qingdong Wang (8988989), Jinming Yang, Kai Guo (54091), Zheng Fang, Jinze Du (8452017), Qingdong Wang, Jinlin Cai, Dong Zhang (73558), Zheng Fang (727034)   +15 more
core   +1 more source

Innovative Developments in the field of Difluoromethylation Chemistry [PDF]

In modern chemistry, the introduction of fluorine atoms is an important field of research and as it permits to tune the biological activity of a molecule.
Selmi Higashi, E
core   +3 more sources

Direct and Regioselective C–H Oxidative Difluoromethylation of Heteroarenes

, 2018
The difluoromethyl group (CF2H) is of great interest in the area of medicinal chemistry. However, the investigation of molecular scaffolds containing this group has been hampered by the limitation of synthetic methods for the introduction of CF2H into ...
Yin-Li Liu (5724230), Feng-Ling Qing (1308318), Huan Li, Huan Li (120482), Xiu-Hua Xu (1383540), Feng-Ling Qing, Sheng-Qing Zhu (5724227), Sheng-Qing Zhu, Xiu-Hua Xu, Yin-Li Liu   +9 more
core   +1 more source

Difluoromethylation–Carboxylation and −Deuteration of Alkenes Triggered by Electroreduction of Difluoromethyltriphenylphosphonium Bromide

It is significant to develop novel difluoromethylation methods because of the important roles of difluoromethyl groups in the medicinal chemistry and material industries.
Jianjun Hao (163767), Fen Han (1734277), Fenfen Xie (17067163), Yunying Yan (17067160), Pan Han (3765889), Linhai Jing (754565), Haiqiong Li (17593785)   +6 more
core   +1 more source

Nickel-Catalyzed Aromatic Cross-Coupling Difluoromethylation of Grignard Reagents with Difluoroiodomethane

, 2018
The nickel-catalyzed cross-coupling difluoromethylation of the Grignard reagents with difluoroiodomethane is shown to provide the corresponding aromatic difluoromethyl products in excellent to moderate yields.
Hirotaka Motohashi (5663489), Koichi Mikami, Koichi Mikami (1470460), Hirotaka Motohashi   +3 more
core   +1 more source

Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes [PDF]

, 2006
The first Lewis acid-catalyzed trifluoromethylation reactions of aldehydes with Me3SiCF3 under TiF4/DMF, Ti(OiPr)4/DMF and Cu(OAc)2/dppp/toluene conditions are described.We have successfully applied this methodology to the difluoromethylation of ...
Toru, Takeshi, Shibata, Norio, Nakamura, Shuichi, Fujimoto, Hiroyuki, Ogawa, Shinichi, Mizuta, Satoshi   +5 more
core   +1 more source

meta-Selective C–H difluoromethylation of various arenes with a versatile ruthenium catalyst

, 2017
A ruthenium-enabled meta-selective C–H difluoromethylation of arenes has been developed.
X. L. Chen, Y. S. Zhao, C. C. Yuan, J. Y. Zhang   +3 more
core   +1 more source

Late stage 18F-difluoromethylation of N-heteroaromatics

, 2019
We herein describe a new methodology for the late stage addition of CHF18F to N-heteroaromatics for PET imaging. This methodology proceeds via C-H activation, under flow photoredox conditions.
Trump, Laura
core  

Effect of 7-Difluoromethyl-5, 4΄-dimethoxygenistein on aorta atherosclerosis in hyperlipidemia ApoE-/- mice induced by a cholesterol-rich diet

Drug Design, Development and Therapy, 2013
Yong Zhang,1,2 Lesai Li,3 Jiliang You,2 Jianguo Cao,2 Xiaohua Fu2 1Department of Hematology, Xiangya Hospital, Central South University, Changsha, People's Republic of China; 2College of Medicine, Hunan Normal University, Changsha, People's ...
Zhang Y, Li L, You J, Cao J, Fu X
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