Results 61 to 70 of about 836 (184)
Electrochemical Difluoromethylation of Electron-Rich Olefins
, 2023 The electrochemical difluoromethylation of electron-rich olefins (enamides and styrene derivatives) is disclosed. The addition of the electrogenerated difluoromethyl radical from the corresponding sodium sulfinate (i.e., HCF2SO2Na) to enamides and ...
Shinan Luan (14716618) +2 more
core +1 more source
Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals
CHIMIA, 2014 Fluorinated compounds are of significant importance in various fields due to their unique chemical, physical, and biological properties. Accordingly, the incorporation of fluorine atom(s) or fluorine-containing functionalities into organic ...
Bing Gao, Chuanfa Ni, Jinbo Hu
doaj +1 more source
Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate [PDF]
Angewandte Chemie, 2013 Difluoromethyl ethers are found increasingly in pharmaceuticals, agrochemicals, and materials.[1] Aryl difluoromethyl ethers are found in medicinally important compounds that include enzyme inhibitors,[2] anti-HIV agents[3] and atimicrobial agents.[4] Pantoprazole (Protonix®), a proton-pump inhibitor, is among the top 100 pharmaceuticals and contains a
Patrick S, Fier, John F, Hartwig
openaire +2 more sources
Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.A sustainable mechanochemical method for C(sp3)–N bond cleavage and in situ N‐formylation of tertiary amines is developed using a difluorocarbene precursor. The transformation proceeds under mild ball‐milling conditions, demonstrating a broad substrate scope, excellent functional group tolerance, and efficient conversions of diverse aliphatic and ...
Yijie Hu +4 more
wiley +1 more source
ScienceOpen Research, 2014 The activation of aromatic diaryl isoxazoles with strong electron-withdrawing groups, such as the nitro, triflyl and the phenylsulfonyl groups, at the 4-position has enabled the first regio- and diastereoselective difluoromethylation at the 5-position of
doaj +3 more sources
Advanced Science, Volume 13, Issue 18, 27 March 2026.Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu +9 more
wiley +1 more source
S‑, N‑, and Se-Difluoromethylation Using Sodium Chlorodifluoroacetate
, 2015 A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 °C to afford difluorocarbene, which can be trapped with a variety ...
Michael F. Greaney (1299891) +1 more
core +1 more source
Copper-Catalyzed Difluoromethylation of Alkyl Halides Enabled by Aryl Radical Activation of Carbon–Halogen Bonds [PDF]
, 2021 The engagement of unactivated alkyl halides in copper-catalyzed cross-coupling reactions has been historically challenging, due to their low reduction potential and the slow oxidative addition of copper(I) catalysts.
Wenhao, Yan, Wei, Liu, Aijie, Cai
core +2 more sources
A water-soluble supermolecular cage for artificial light-harvesting nanoreactors
Green Synthesis and CatalysisTwo discrete octahedral metallo-supramolecular cages were designed and constructed by using truxene-based pyridine L with enPd(NO3)2 or enPt(NO3)2, followed by detailed NMR, MS, UV absorption, and fluorescence spectroscopy. Owing to the determined cavity
Xin Han +4 more
doaj +1 more source
Divergent Regioselective Csp2–H Difluoromethylation of Aromatic Amines Enabled by Nickel Catalysis
, 2022 Herein, the first catalytic protocol for nickel-catalyzed ortho or para position difluoromethylation of various aromatic amines has been developed with the assistance of a bidentate phosphine ligand, offering an invaluable synthesis means to construct ...
Wei Yi +15 more
core +1 more source