Results 41 to 50 of about 836 (184)
Sequential C-Selective Difluoromethylation/Pd-Catalyzed Decarboxylative Protonation: An Efficient Access to Tertiary Difluoromethylated Scaffolds [PDF]
, 2019 We report here a general method that allows a highly straightforward access to tertiary difluoromethylated compounds. The strategy relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and an unprecedented palladium ...
Nicolas, Duchemin +4 more
core +2 more sources
Beilstein Journal of Organic Chemistry, 2013 In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research.
Grégory Landelle +4 more
doaj +1 more source
Synthesis of α-Difluoromethyl Aryl Ketones through a Photoredox Difluoromethylation of Enol Silanes
Organic Letters, 2021 We report here an efficient and highly straightforward access to α-difluoromethylated ketones through a visible light-mediated difluoromethylation of readily available enol silanes. The method, which takes advantage of the polyvalence of Hu's reagent, N-tosyl-S-difluoromethyl-S-phenylsulfoximine, used here as a CHF2 radical precursor under catalytic ...
Selmi-Higashi, Elias +3 more
openaire +3 more sources
Development of a General Automated Flow Photoredox 18F-Difluoromethylation of N-Heteroaromatics in an AllinOne Synthesizer [PDF]
, 2020 peer reviewedWe recently reported a new method for the 18F-difluoromethylation of N-heteroaromatics for positron emission tomography (PET) imaging.
Mercier, Joël +17 more
core +1 more source
Synthetic Methods for Four-Membered Carbocycles Bearing Emerging Fluorinated Motifs. [PDF]
Chem Asian JIn this review, we provide an overview of four‐membered carbocycles with “emerging” fluorine‐containing motifs, including mono, di, and trifluoromethyl groups, sulfur‐ and other hetero atom‐linked substituents. Such molecular structures are well utilized as one of the recent trends in drug design. Recent progress of cyclobutane‐based polycyclic systems,
Yanai H +3 more
europepmc +2 more sources
High‐Valent Copper(III) Compounds: Structural Diversity and Versatile Applications
ChemistryEurope, Volume 4, Issue 9, September 2026.In the past decade, copper(III) complexes have emerged from elusive intermediates to a class of well‐defined complexes with rich coordination chemistry, structural diversity, and synthetic applications. This review summarizes synthetic strategies for accessing Cu(III) oxidation state across varied coordination environments and highlights their ...
Vladimir Motornov
wiley +1 more source
Mechanochemistry as an Emerging Tool for Organofluorine Chemistry
Chemistry–Methods, Volume 6, Issue 8, August 2026.Fluorinated scaffolds are central across many areas of chemistry, driving the demand for efficient and sustainable synthetic methods. Mechanochemistry has emerged as a powerful alternative to conventional approaches, offering reduced environmental impact, shorter reaction times, and unique reactivity and selectivity.
Marie Caldiero +3 more
wiley +1 more source
Visible Light-Mediated C–H Difluoromethylation of Electron-Rich Heteroarenes
, 2016 A novel method for visible-light photoredox-catalyzed difluoromethylation of electron-rich N-, O-, and S-containingheteroarenes under mild reaction conditions is developed. Mechanistic investigation indicates that the net C–H difluoromethylation proceeds
Yue-Ming Xu (1796218) +6 more
core +1 more source
Flow‐Enabled, Modular Access to α,α‐Difluoromethylene Amines
Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.We report a safe and scalable flow‐based strategy for the on‐demand generation of NCF2R anions using a packed‐bed microreactor containing CsF. This protocol enables the late‐stage installation of the CF2 group under mild conditions leveraging three points of diversification, allowing efficient access to a broad range of NCF2R scaffolds.
Dmitrii Nagornîi +5 more
wiley +2 more sources
Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
Nature Communications, 2018 Selective para-functionalization of substituted arenes is a formidable challenge in homogeneous catalysis. Here, the authors achieved the para-selective C-H difluoromethylation of anilides, indolines and tetrahydroquinolines with a ruthenium catalyst in ...
Chunchen Yuan +6 more
doaj +1 more source