Results 41 to 50 of about 375 (147)

Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

Nature Communications, 2018
Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and ...
Chang Xu, Wen-Hao Guo, Xu He, Yin-Long Guo, Xue-Ying Zhang, Xingang Zhang   +5 more
doaj   +1 more source

Trifluoromethylation‐Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids

ChemistryOpen, Volume 15, Issue 8, August 2026.
Fluorinated drugs often contain trifluoromethyl groups. The increasing importance of such drugs has resulted in more and more attention toward new or improved trifluoromethylation reactions. This review discusses possible reaction mechanisms and existing methods for one such process, trifluoromethylation‐induced lactonization, a distant relative of the
Attila M. Remete
wiley   +1 more source

Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives

Nature Communications, 2018
Selective para-functionalization of substituted arenes is a formidable challenge in homogeneous catalysis. Here, the authors achieved the para-selective C-H difluoromethylation of anilides, indolines and tetrahydroquinolines with a ruthenium catalyst in ...
Chunchen Yuan, Lei Zhu, Changpeng Chen, Xiaolan Chen, Yong Yang, Yu Lan, Yingsheng Zhao   +6 more
doaj   +1 more source

Emerging Trends in Organic Photoreactions Utilizing Disulfides

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
Disulfides are versatile, nontoxic alternatives to metal photocatalysts. This review explores their role as photoactivated thiyl‐radical precursors and bifunctional catalysts (HAT/electron shuttling) in diverse transformations. Strategies for electronic tuning and development into recyclable heterogeneous materials are highlighted for sustainable ...
Sunil Kumar, Bolormaa Bayarkhuu, Hong Y. Cho, Jeehye Byun   +3 more
wiley   +1 more source

Copper Joins the Monoelectronic Game: Leveraging the CuI Potential for SET‐, XAT‐, and HAT‐Driven Catalytic Organic Synthesis

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
This review surveys the emerging role of copper(I) catalysis in sustainable synthesis, highlighting its exceptional capacity for monoelectronic processes. By examining the strategies based on electron, halogen, and hydrogen transfer processes (SET, XAT, and HAT, respectively), we outline key reactivity trends, design principles, and the synthetic ...
Antonio Torres‐Calis, Juventino J. García   +1 more
wiley   +1 more source

Mechanochemical Difluorocarbene‐Mediated C(sp3)–N Bond Cleavage and In Situ Formylation of Tertiary Amines

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
A sustainable mechanochemical method for C(sp3)–N bond cleavage and in situ N‐formylation of tertiary amines is developed using a difluorocarbene precursor. The transformation proceeds under mild ball‐milling conditions, demonstrating a broad substrate scope, excellent functional group tolerance, and efficient conversions of diverse aliphatic and ...
Yijie Hu, Peng Wu, Chandan Chittapriya Sahu, Kari Rissanen, Carsten Bolm   +4 more
wiley   +1 more source

Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang   +9 more
wiley   +1 more source

Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals

CHIMIA, 2014
Fluorinated compounds are of significant importance in various fields due to their unique chemical, physical, and biological properties. Accordingly, the incorporation of fluorine atom(s) or fluorine-containing functionalities into organic ...
Bing Gao, Chuanfa Ni, Jinbo Hu
doaj   +1 more source

Direct Nucleophilic Difluoromethylation of Aromatic Isoxazoles Activated by Electron-Withdrawing Groups Using (Difluoromethyl)trimethylsilane

ScienceOpen Research, 2014
The activation of aromatic diaryl isoxazoles with strong electron-withdrawing groups, such as the nitro, triflyl and the phenylsulfonyl groups, at the 4-position has enabled the first regio- and diastereoselective difluoromethylation at the 5-position of
doaj   +3 more sources

A water-soluble supermolecular cage for artificial light-harvesting nanoreactors

Green Synthesis and Catalysis
Two discrete octahedral metallo-supramolecular cages were designed and constructed by using truxene-based pyridine L with enPd(NO3)2 or enPt(NO3)2, followed by detailed NMR, MS, UV absorption, and fluorescence spectroscopy. Owing to the determined cavity
Xin Han, Luyao Ding, Xin-Qi Hao, Yujing Guo, Linlin Shi   +4 more
doaj   +1 more source