Results 31 to 40 of about 375 (147)

Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate [PDF]

Angewandte Chemie, 2013
Difluoromethyl ethers are found increasingly in pharmaceuticals, agrochemicals, and materials.[1] Aryl difluoromethyl ethers are found in medicinally important compounds that include enzyme inhibitors,[2] anti-HIV agents[3] and atimicrobial agents.[4] Pantoprazole (Protonix®), a proton-pump inhibitor, is among the top 100 pharmaceuticals and contains a
Patrick S, Fier, John F, Hartwig
openaire   +2 more sources

Synthesis of α-Difluoromethyl Aryl Ketones through a Photoredox Difluoromethylation of Enol Silanes

Organic Letters, 2021
We report here an efficient and highly straightforward access to α-difluoromethylated ketones through a visible light-mediated difluoromethylation of readily available enol silanes. The method, which takes advantage of the polyvalence of Hu's reagent, N-tosyl-S-difluoromethyl-S-phenylsulfoximine, used here as a CHF2 radical precursor under catalytic ...
Selmi-Higashi, Elias, Zhang, Jinlei, Cambeiro, Xacobe C., Arseniyadis, Stellios   +3 more
openaire   +3 more sources

O- and N-Difluoromethylation of 2-Pyridones with Chlorodifluoromethane

Журнал органічної та фармацевтичної хімії
Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence ...
Kirill I. Petko, Andrey A. Filatov
doaj   +1 more source

Cathodic generation of reactive (phenylthio)difluoromethyl species and its reactions: mechanistic aspects and synthetic applications

Beilstein Journal of Organic Chemistry, 2022
The cathodic reduction of bromodifluoromethyl phenyl sulfide (1) using o-phthalonitrile as a mediator generated the (phenylthio)difluoromethyl radical, which reacted with α-methylstyrene and 1,1-diphenylethylene to provide the corresponding adducts in ...
Sadanobu Iwase, Shinsuke Inagi, Toshio Fuchigami   +2 more
doaj   +1 more source

Development of direct C-3 difluoromethylation reaction for application in synthesis of quinoline-related drugs

Vietnam Journal of Science, Technology and Engineering
Fluorine holds a prominent position within the realm of drug discovery and development, substantiated by its presence in approximately 25% of drugs approved by the US Food and Drug Administration (FDA).
Thanh Tung Truong, John Nielsen
doaj   +1 more source

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Beilstein Journal of Organic Chemistry, 2013
In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research.
Grégory Landelle, Armen Panossian, Sergiy Pazenok, Jean-Pierre Vors, Frédéric R. Leroux   +4 more
doaj   +1 more source

Deprotonative Functionalization of the Difluoromethyl Group

Organic Letters, 2020
The functionalization of 3-(difluoromethyl)pyridine has been developed via direct deprotonation of -CHF2 with a lithiated base and subsequent trapping with various electrophiles in THF. In situ quenching gives access to 3-pyridyl-CF2-SiMe2Ph as a new silylated compound, which can be postfunctionalized with a fluoride source to obtain a larger library ...
Santos, Laura, Panossian, Armen, Donnard, Morgan, Vors, Jean-Pierre, Pazenok, Sergii, Bernier, David, Leroux, Frédéric   +6 more
openaire   +4 more sources

Porous Organic Polymers: From Molecular Design to Scalable Technologies

Small, EarlyView.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem, Hadi Shayesteh, Simindokht Zarei‐Shokat, Rokhsareh Bakhtiari, Sheyda Abedi‐Banaei, Zahra Sheikhlouiharzand, Parnia Mohebimanesh, Seyed Mohammad Amin Ojagh, Bahareh Bakhtiari, Ali Maleki, Theo G. M. van de Ven, Sohrab Zendehboudi, Ali Elkamel   +12 more
wiley   +1 more source

A New Reagent for Direct Difluoromethylation [PDF]

Journal of the American Chemical Society, 2012
Molecular scaffolds containing alkylfluorine substituents are desired in many areas of chemical research from materials to pharmaceuticals. Herein, we report the invention of a new reagent (Zn(SO(2)CF(2)H)(2), DFMS) for the innate difluoromethylation of organic substrates via a radical process.
Yuta, Fujiwara, Janice A, Dixon, Rodrigo A, Rodriguez, Ryan D, Baxter, Darryl D, Dixon, Michael R, Collins, Donna G, Blackmond, Phil S, Baran   +7 more
openaire   +2 more sources

Mechanochemistry as an Emerging Tool for Organofluorine Chemistry

Chemistry–Methods, Volume 6, Issue 8, August 2026.
Fluorinated scaffolds are central across many areas of chemistry, driving the demand for efficient and sustainable synthetic methods. Mechanochemistry has emerged as a powerful alternative to conventional approaches, offering reduced environmental impact, shorter reaction times, and unique reactivity and selectivity.
Marie Caldiero, Nicolas Delcroix, Vitalii Solomin, Thomas Castanheiro   +3 more
wiley   +1 more source