Results 31 to 40 of about 836 (184)

Development of late-stage difluoromethylation strategies [PDF]

, 2021
In the last decades, the introduction of the difluoromethyl group has attracted many interests in drug discovery. This thesis discusses the development of novel strategies for the late-stage introduction of the difluoromethyl group in the context of ...
Meyer, Claudio Flavio
core   +1 more source

3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents

Nature Communications, 2021
Synthesis of fluorinated organic molecules is of high interest for agrochemistry and pharmaceutics, but efficient and general reagents for introducing -CF2- groups are lacking.
Fei Ye, Yao Ge, Anke Spannenberg, Helfried Neumann, Li-Wen Xu, Matthias Beller   +5 more
doaj   +1 more source

(Sila)Difluoromethylation of Fluorenyllithium with CF3H and CF3TMS

SynOpen, 2018
Difluoromethylation of the C9-H site of the fluorene ring using lithium base and fluoroform (CF3H), which is one of the most cost-effective difluoromethylating reagents, is attained to give difluoromethylated fluorenes with an all-carbon quaternary ...
Kenichi Maruyama, Daichi Saito, Koichi Mikami   +2 more
doaj   +1 more source

Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F)

Beilstein Journal of Organic Chemistry, 2020
Over the years, the development of new methodologies for the introduction of various fluorinated motifs has gained a significant interest due to the importance of fluorine-containing molecules in the pharmaceutical and agrochemical industries. In a world
Louise Ruyet, Tatiana Besset
doaj   +1 more source

Visible Light-Induced Radical Cascade Difluoromethylation/Cyclization of Unactivated Alkenes: Access to CF2H‑Substituted Polycyclic Imidazoles [PDF]

ACS Omega
Sheng-Nan Lin, Yuanyuan Deng, Hanxun Zhong, Liu-Liang Mao, Cong-Bin Ji, Xian-Hong Zhu, Xiaolan Zhang, Bin-Miao Yang   +7 more
doaj   +2 more sources

Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

Nature Communications, 2021
Compounds that contain alkyl-difluoromethyl moieties are of interest for medicinal chemistry, but their synthesis is challenging. Here, the authors report a copper-catalyzed radical relay approach for the carbodifluoromethylation of alkenes that ...
Aijie Cai, Wenhao Yan, Xiaojun Zeng, Samson B. Zacate, Tzu-Hsuan Chao, Jeanette A. Krause, Mu-Jeng Cheng, Wei Liu   +7 more
doaj   +1 more source

O- and N-Difluoromethylation of 2-Pyridones with Chlorodifluoromethane

Журнал органічної та фармацевтичної хімії
Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence ...
Kirill I. Petko, Andrey A. Filatov
doaj   +1 more source

Cathodic generation of reactive (phenylthio)difluoromethyl species and its reactions: mechanistic aspects and synthetic applications

Beilstein Journal of Organic Chemistry, 2022
The cathodic reduction of bromodifluoromethyl phenyl sulfide (1) using o-phthalonitrile as a mediator generated the (phenylthio)difluoromethyl radical, which reacted with α-methylstyrene and 1,1-diphenylethylene to provide the corresponding adducts in ...
Sadanobu Iwase, Shinsuke Inagi, Toshio Fuchigami   +2 more
doaj   +1 more source

Direct 1,6-Difluoromethylation of 3‑Methyl-4-nitro-5-styryl Isoxazoles by Photoredox-Promoted Radical Addition

, 2023
The photoredox-catalyzed 1,6-difluoromethylation of 3-methyl-4-nitro-5-styrylisoxazole with HCF2SO2Na has been developed. Structurally diverse difluoromethylated products were obtained in good yields, and their further transformations were also ...
Yingqian Xu (452230), Jianguo Yang (1416394), Shaorui Song, Aiguo Zhong, Jianguo Yang, Jianli Zheng, Ling Huang, Dingben Chen (2274364), Jianli Zheng (2180784), Ling Huang (51752), Shaorui Song (16534103), Dongdong Cao, Dingben Chen, Yingqian Xu, Dongdong Cao (350033), Aiguo Zhong (2029669)   +15 more
core   +1 more source

Development of direct C-3 difluoromethylation reaction for application in synthesis of quinoline-related drugs

Vietnam Journal of Science, Technology and Engineering
Fluorine holds a prominent position within the realm of drug discovery and development, substantiated by its presence in approximately 25% of drugs approved by the US Food and Drug Administration (FDA).
Thanh Tung Truong, John Nielsen
doaj   +1 more source