Results 51 to 60 of about 836 (184)

Trifluoromethylation‐Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids

ChemistryOpen, Volume 15, Issue 8, August 2026.
Fluorinated drugs often contain trifluoromethyl groups. The increasing importance of such drugs has resulted in more and more attention toward new or improved trifluoromethylation reactions. This review discusses possible reaction mechanisms and existing methods for one such process, trifluoromethylation‐induced lactonization, a distant relative of the
Attila M. Remete
wiley   +1 more source

Direct Nucleophilic Difluoromethylation of Carbonyl Compounds

, 2016
Phosphonium salt ([Ph3P+CF2H] Br–, DFPB) was found to be an efficient nucleophilic difluoromethylation reagent. Although DFPB is known as a phosphonium ylide precursor, its reaction with carbonyl compounds under traditional “Wittig reaction conditions ...
Ji-Chang Xiao (1457842), Zuyong Deng (2822822), Jin-Hong Lin (1457833), Ji Cai (1778686)   +3 more
core   +1 more source

Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides [PDF]

, 2017
A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described.
Qilong Shen, Yang Gu, Yucheng Gu, Wu, Jiang, Shen, Qilong, Gu, Yucheng, Changhui Lu, Jiang Wu, Gu, Yang, Lu, Changhui   +9 more
core   +1 more source

State of knowledge in photoredox-catalysed direct difluoromethylation

, 2022
International audienceThe combination of visible light photoredox catalysis with direct difluoromethylation has allowed the synthesis of a large choice of CF 2 H-containing value-added molecules under very mild reaction ...
Jia, Xiaodong, Zhang, Shuyue, Cahard, Dominique, Feng, Jiaxu, Lu, Kui   +4 more
core   +1 more source

Deprotonative Functionalization of the Difluoromethyl Group

Organic Letters, 2020
The functionalization of 3-(difluoromethyl)pyridine has been developed via direct deprotonation of -CHF2 with a lithiated base and subsequent trapping with various electrophiles in THF. In situ quenching gives access to 3-pyridyl-CF2-SiMe2Ph as a new silylated compound, which can be postfunctionalized with a fluoride source to obtain a larger library ...
Santos, Laura, Panossian, Armen, Donnard, Morgan, Vors, Jean-Pierre, Pazenok, Sergii, Bernier, David, Leroux, Frédéric   +6 more
openaire   +4 more sources

Porous Organic Polymers: From Molecular Design to Scalable Technologies

Small, Volume 22, Issue 46, 18 August 2026.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem, Hadi Shayesteh, Simindokht Zarei‐Shokat, Rokhsareh Bakhtiari, Sheyda Abedi‐Banaei, Zahra Sheikhlouiharzand, Parnia Mohebimanesh, Seyed Mohammad Amin Ojagh, Bahareh Bakhtiari, Ali Maleki, Theo G. M. van de Ven, Sohrab Zendehboudi, Ali Elkamel   +12 more
wiley   +1 more source

Copper-Catalyzed, Chloroamide-Directed Benzylic C–H Difluoromethylation

, 2019
We report herein the first catalytic strategy to harness amidyl radicals derived from N-chloroamides for C–C bond formation, allowing for the discovery of the first catalytic benzylic C–H difluoromethylation.
Yufei Wang, Matthew Paeth (6308399), Wenhao Yan, Tao Yan (429415), Chang Song (172416), Matthew Paeth, Tao Yan, Dongqi Yang, Zhi Cao (614116), Wenhao Yan (160979), Kundi Yang (6308411), Pei-Hsun Hong, Dongqi Yang (1482406), Samson B. Zacate (6949253), Zhi Cao, Kundi Yang, Pei-Hsun Hong (8097824), Wei Liu (20030), Yufei Wang (171069), Chang Song, Samson B. Zacate, Xiaojun Zeng (1968298), Mu-Jeng Cheng, Mu-Jeng Cheng (1505026), Xiaojun Zeng, Wei Liu   +25 more
core   +1 more source

Emerging Trends in Organic Photoreactions Utilizing Disulfides

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
Disulfides are versatile, nontoxic alternatives to metal photocatalysts. This review explores their role as photoactivated thiyl‐radical precursors and bifunctional catalysts (HAT/electron shuttling) in diverse transformations. Strategies for electronic tuning and development into recyclable heterogeneous materials are highlighted for sustainable ...
Sunil Kumar, Bolormaa Bayarkhuu, Hong Y. Cho, Jeehye Byun   +3 more
wiley   +1 more source

Copper Joins the Monoelectronic Game: Leveraging the CuI Potential for SET‐, XAT‐, and HAT‐Driven Catalytic Organic Synthesis

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
This review surveys the emerging role of copper(I) catalysis in sustainable synthesis, highlighting its exceptional capacity for monoelectronic processes. By examining the strategies based on electron, halogen, and hydrogen transfer processes (SET, XAT, and HAT, respectively), we outline key reactivity trends, design principles, and the synthetic ...
Antonio Torres‐Calis, Juventino J. García   +1 more
wiley   +1 more source

A New Reagent for Direct Difluoromethylation [PDF]

Journal of the American Chemical Society, 2012
Molecular scaffolds containing alkylfluorine substituents are desired in many areas of chemical research from materials to pharmaceuticals. Herein, we report the invention of a new reagent (Zn(SO(2)CF(2)H)(2), DFMS) for the innate difluoromethylation of organic substrates via a radical process.
Yuta, Fujiwara, Janice A, Dixon, Rodrigo A, Rodriguez, Ryan D, Baxter, Darryl D, Dixon, Michael R, Collins, Donna G, Blackmond, Phil S, Baran   +7 more
openaire   +2 more sources