Results 21 to 30 of about 836 (184)
Sulfone Electrophiles in Cross-Electrophile Coupling: Nickel-Catalyzed Difluoromethylation of Aryl Bromides. [PDF]
ACS CatalFluoroalkyl fragments have played a critical role in the design of pharmaceutical and agrochemical molecules in recent years due to the enhanced biological properties of fluorinated molecules compared to their non-fluorinated analogues.
Chi BK +5 more
europepmc +3 more sources
Nickel-catalyzed Difluoromethylation of Alkene using Difluoroacetic Anhydride [PDF]
, 2023 Herein, we describe a nickel-catalyzed reductive difluoromethylation reaction of alkene using inexpensive and easy-to-handle DFAA/pyridine N-oxide reagent system.
Hui, Chen, Xuebin, Liao, Zhenkang, Ai
core +2 more sources
Molecules, 2022 A reagent-controlled highly stereoselective reaction between (S)-difluoromethyl phenyl sulfoximine 1 and imines is reported, and this synthetic method provides a variety of enantiomerically enriched α-difluoromethyl amines. The main pros of this approach
Qinghe Liu +3 more
doaj +1 more source
Nucleophilic Difluoromethylation of Primary Alkyl Halides Using Difluoromethyl Phenyl Sulfone as a Difluoromethyl Anion Equivalent. [PDF]
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
G K Surya, Prakash +3 more
openaire +2 more sources
Late-stage difluoromethylation: concepts, developments and perspective [PDF]
, 2021 This review describes the recent advances made in difluoromethylation processes based on X–CF2H bond formation where X is C(sp), C(sp2), C(sp3), O, N or S, a field of research that has benefited from the invention of multiple difluoromethylation reagents.
Trabanco, Andrés A +6 more
core +1 more source
Pharmaceuticals, 2022 CF2H moiety has a significant potential utility in drug design and discovery, and the incorporation of CF2H into biologically active molecules represents an important and efficient strategy for seeking lead compounds and drug candidates.
Kai-Zhong Fu +4 more
doaj +1 more source
A New Reagent for Direct Difluoromethylation
, 2016 Molecular scaffolds containing alkylfluorine substituents are desired in many areas of chemical research from materials to pharmaceuticals. Herein, we report the invention of a new reagent (Zn(SO2CF2H)2, DFMS) for the innate difluoromethylation of ...
Ryan D. Baxter (1247007) +7 more
core +4 more sources
Beilstein Journal of Organic Chemistry, 2023 Nitrogen-containing organofluorine derivatives, which are prepared using fluorinated building blocks, are among the most important active fragments in various pharmaceutical and agrochemical products. This review focuses on the reactivity, synthesis, and
Zhang Dongxu
doaj +1 more source
New Electrophilic Difluoromethylating Reagent [PDF]
Organic Letters, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
G K Surya, Prakash +3 more
openaire +2 more sources
Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis
Nature Communications, 2020 Heterocycles containing difluoromethyl groups are molecules with potential application in pharmaceutical, agricultural and materials science. Here, the authors show an organophotocatalytic difluoromethylation of heterocycles using O2 as green oxidant and
Wei Zhang +7 more
doaj +1 more source