Results 1 to 10 of about 375 (147)

Chemoselective Difluoromethylation of Nucleosides. [PDF]

Org Lett
A profiling platform to define the chemoselectivity of the carbene-mediated difluoromethylation of nucleosides is described. First, the optimized reaction conditions for the difluoromethylation of silyl-protected nucleosides are established using TMS-CF2Br and KOAc to form the difluoromethyl carbene in situ.
Linden O, Axer A, Taladriz-Sender A, Burley GA.   +3 more
europepmc   +4 more sources

Dual transition metal electrocatalysis for difluoromethylation of Aryl halides using potassium difluoroacetate [PDF]

Nature Communications
The development of robust, practical, and chemoselective methods for introducing the difluoromethyl (CF₂H) group into organic molecules is highly sought after in the fields of pharmaceutical and agrochemical design.
Naifu Zhou, Mingding Chai, Niankai Fu
doaj   +2 more sources

Facile Entry to Pharmaceutically Important 3-Difluoromethyl-quinoxalin-2-ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-ones [PDF]

Pharmaceuticals, 2022
CF2H moiety has a significant potential utility in drug design and discovery, and the incorporation of CF2H into biologically active molecules represents an important and efficient strategy for seeking lead compounds and drug candidates.
Kai-Zhong Fu, Xu-Xin Chen, Ya-Shi Zhao, Yuan-Qing Gu, Guo-Kai Liu   +4 more
doaj   +2 more sources

Repurposing trifluoromethyl copper (III) complexes for difluoromethylation of saccharides and complex alcohols [PDF]

Nature Communications
Grushin’s reagent, (bpy)Cu(CF3)3, is a well-known trifluoromethylation agent, but its potential as a difluorocarbene source has remained largely unexplored.
Shuolu Dai, Chuhong Xie, Shan Long, Min Luo, Chen Chen, Tingting Li, Wen-Xin Lv, Yonggui Robin Chi   +7 more
doaj   +2 more sources

Ball-Milling Assisted Iron-Catalyzed Difluoromethylation Toward the Synthesis of Valuable Oxindoles. [PDF]

ChemSusChem
An iron‐catalyzed difluoroalkylation of acrylamides under ball‐milling conditions affords oxindoles in up to 85% yield. Analytical studies reveal that the apparent piezoelectric activity originates from iron leaching caused by milling assembly abrasion during the reaction process. The iron‐catalyzed process proves to be efficient with a broad substrate
Solomin V, Delcroix N, Caldiero M, Jubault P, Castanheiro T.   +4 more
europepmc   +2 more sources

Defluoroalkylation of Trifluoromethane with Organolithium Reagents: Mechanism and Synthesis of Fluoroalkenes. [PDF]

Angew Chem Int Ed Engl
We report a rare example of the transformation of HCF3 into a fluoroalkene functional group through defluoroalkylation. We rationalise product formation through DFT calculations, scale‐up the synthesis through continuous flow methods, and show that a fluoroalkene reagent derived from HCF3 is a competent nucleophile for the fluoroethenylation of a range
Warsame HR, Patrick SL, Bull JA, Miller PW, Crimmin MR.   +4 more
europepmc   +3 more sources

Synthetic Strategies to Access Fluorinated Azoles. [PDF]

European J Org Chem
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
El-Gaber MKA, Djugovski M, Huang TY, Adhikari S, Roy S.   +4 more
europepmc   +2 more sources

Advances in the Different Synthetic Routes of Fluorinated Hydrazines. [PDF]

Chem Rec
This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Kyrko D, Crousse B.
europepmc   +2 more sources

Mechanochemical difluoromethylations of ketones. [PDF]

Beilstein J Org Chem
We present a mechanochemical synthesis of difluoromethyl enol ethers. Utilizing an in situ generation of difluorocarbenes, ketones are efficiently converted to the target products under solvent-free conditions. The reactions proceed at room temperature and are complete within 90 minutes, demonstrating both efficiency and experimental simplicity.
Ke J, van Bonn P, Bolm C.
europepmc   +4 more sources

Introduction of the difluoromethyl group at the meta- or para-position of pyridines through regioselectivity switch [PDF]

Nature Communications
Difluoromethyl pyridines have gained significant attention in medicinal and agricultural chemistry. The direct C−H-difluoromethylation of pyridines represents a highly efficient economic way to access these azines.
Pengwei Xu, Zhe Wang, Shu-Min Guo, Armido Studer   +3 more
doaj   +2 more sources