Results 1 to 10 of about 367 (137)

Chemoselective Difluoromethylation of Nucleosides. [PDF]

Org Lett
A profiling platform to define the chemoselectivity of the carbene-mediated difluoromethylation of nucleosides is described. First, the optimized reaction conditions for the difluoromethylation of silyl-protected nucleosides are established using TMS-CF2Br and KOAc to form the difluoromethyl carbene in situ.
Linden O, Axer A, Taladriz-Sender A, Burley GA.   +3 more
europepmc   +4 more sources

Dual transition metal electrocatalysis for difluoromethylation of Aryl halides using potassium difluoroacetate [PDF]

Nature Communications
The development of robust, practical, and chemoselective methods for introducing the difluoromethyl (CF₂H) group into organic molecules is highly sought after in the fields of pharmaceutical and agrochemical design.
Naifu Zhou, Mingding Chai, Niankai Fu
doaj   +2 more sources

Repurposing trifluoromethyl copper (III) complexes for difluoromethylation of saccharides and complex alcohols [PDF]

Nature Communications
Grushin’s reagent, (bpy)Cu(CF3)3, is a well-known trifluoromethylation agent, but its potential as a difluorocarbene source has remained largely unexplored.
Shuolu Dai, Chuhong Xie, Shan Long, Min Luo, Chen Chen, Tingting Li, Wen-Xin Lv, Yonggui Robin Chi   +7 more
doaj   +2 more sources

Electrosynthesis of 1,1-Bis(difluoromethyl)alkenes via Twofold C−H Difluoromethylation as Bioisosteres of Elusive 1,1-Enediols [PDF]

Nature Communications
Geminal bis(difluoromethyl)alkenes, featuring two CF2H groups as lipophilic hydrogen-bond donor surrogates, are highly coveted yet rarely accessible bioisosteres of 1,1-enediols that remain nearly theoretical due to their inherent instability.
Seonyoung Kim, Eunji Kwon, Sung Bum Park, Areum Park, Hyuk Lee, Hyunwoo Kim   +5 more
doaj   +2 more sources

Mechanochemical difluoromethylations of ketones. [PDF]

Beilstein J Org Chem
We present a mechanochemical synthesis of difluoromethyl enol ethers. Utilizing an in situ generation of difluorocarbenes, ketones are efficiently converted to the target products under solvent-free conditions. The reactions proceed at room temperature and are complete within 90 minutes, demonstrating both efficiency and experimental simplicity.
Ke J, van Bonn P, Bolm C.
europepmc   +4 more sources

Introduction of the difluoromethyl group at the meta- or para-position of pyridines through regioselectivity switch [PDF]

Nature Communications
Difluoromethyl pyridines have gained significant attention in medicinal and agricultural chemistry. The direct C−H-difluoromethylation of pyridines represents a highly efficient economic way to access these azines.
Pengwei Xu, Zhe Wang, Shu-Min Guo, Armido Studer   +3 more
doaj   +2 more sources

Metallaphotoredox Difluoromethylation of Aryl Bromides [PDF]

Angewandte Chemie - International Edition, 2018
AbstractHerein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl‐radical‐mediated halogen abstraction.
Masaru Kondo, David W. C. MacMillan, Vlad Bacauanu   +2 more
exaly   +3 more sources

Visible-light-promoted radical cyclisation of unactivated alkenes in benzimidazoles: synthesis of difluoromethyl- and aryldifluoromethyl-substituted polycyclic imidazoles [PDF]

Beilstein Journal of Organic Chemistry
An efficient and eco-friendly approach for synthesizing difluoromethyl- and aryldifluoromethyl-substituted polycyclic imidazoles was established via a visible-light-promoted radical cyclization reaction.
Yujun Pang, Jinglan Yan, Nawaf Al-Maharik, Qian Zhang, Zeguo Fang, Dong Li   +5 more
doaj   +2 more sources

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene [PDF]

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +2 more sources

1,6-Nucleophilic Di- and Trifluoromethylation of para-Quinone Methides with Me₃SiCF₂H/Me₃SiCF₃ Facilitated by CsF/18-Crown-6 [PDF]

Molecules
The direct 1,6-nucleophilic difluoromethylation, trifluoromethylation, and difluoroalkylation of para-quinone methides (p-QMs) with Me3SiRf (Rf = CF2H, CF3, CF2CF3, CF2COOEt, and CF2SPh) under mild conditions are described. Although Me3SiCF2H shows lower
Dingben Chen, Ling Huang, Mingyu Liang, Xiaojing Chen, Dongdong Cao, Pan Xiao, Chuanfa Ni, Jinbo Hu   +7 more
doaj   +2 more sources