Results 11 to 20 of about 375 (147)

Visible-light-promoted radical cyclisation of unactivated alkenes in benzimidazoles: synthesis of difluoromethyl- and aryldifluoromethyl-substituted polycyclic imidazoles [PDF]

Beilstein Journal of Organic Chemistry
An efficient and eco-friendly approach for synthesizing difluoromethyl- and aryldifluoromethyl-substituted polycyclic imidazoles was established via a visible-light-promoted radical cyclization reaction.
Yujun Pang, Jinglan Yan, Nawaf Al-Maharik, Qian Zhang, Zeguo Fang, Dong Li   +5 more
doaj   +2 more sources

Metallaphotoredox Difluoromethylation of Aryl Bromides [PDF]

Angewandte Chemie - International Edition, 2018
AbstractHerein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl‐radical‐mediated halogen abstraction.
Masaru Kondo, David Macmillan, Vlad Bacauanu   +2 more
exaly   +3 more sources

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene [PDF]

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +2 more sources

1,6-Nucleophilic Di- and Trifluoromethylation of para-Quinone Methides with Me₃SiCF₂H/Me₃SiCF₃ Facilitated by CsF/18-Crown-6 [PDF]

Molecules
The direct 1,6-nucleophilic difluoromethylation, trifluoromethylation, and difluoroalkylation of para-quinone methides (p-QMs) with Me3SiRf (Rf = CF2H, CF3, CF2CF3, CF2COOEt, and CF2SPh) under mild conditions are described. Although Me3SiCF2H shows lower
Dingben Chen, Ling Huang, Mingyu Liang, Xiaojing Chen, Dongdong Cao, Pan Xiao, Chuanfa Ni, Jinbo Hu   +7 more
doaj   +2 more sources

Flow-Enabled, Modular Access to α,α-Difluoromethylene Amines. [PDF]

Angew Chem Int Ed Engl
We report a safe and scalable flow‐based strategy for the on‐demand generation of NCF2R anions using a packed‐bed microreactor containing CsF. This protocol enables the late‐stage installation of the CF2 group under mild conditions leveraging three points of diversification, allowing efficient access to a broad range of NCF2R scaffolds.
Nagornîi D, Ronco P, Anwar K, Kaplaneris N, Douglas JJ, Noël T.   +5 more
europepmc   +3 more sources

Tetrafluoroisopropylation of alkenes and alkynes enabled by photocatalytic consecutive difluoromethylation with CF2HSO2Na [PDF]

Nature Communications
Direct assembly of complex fluorinated motifs from simple fluorine sources is an attractive frontier of synthetic chemistry. Reported herein is an unconventional protocol for achieving tetrafluoroisopropylation by using commercially available CF2HSO2Na ...
Yuwei Hong, Jiayan Qiu, Zhenzhen Wu, Sangxuan Xu, Hanliang Zheng, Gangguo Zhu   +5 more
doaj   +2 more sources

Highly Enantioselective Decarboxylative Difluoromethylation. [PDF]

J Am Chem Soc
Organofluorine molecules that contain difluoromethyl groups (CF2H) at stereogenic centers have gained importance in pharmaceuticals due to the unique ability of CF2H groups to act as lipophilic hydrogen bond donors. Despite their potential, the enantioselective installation of CF2H groups into readily available starting materials remains a challenging ...
Zhao X, Wang C, Yin L, Liu W.
europepmc   +3 more sources

Synthetic Methods for Four-Membered Carbocycles Bearing Emerging Fluorinated Motifs. [PDF]

Chem Asian J
In this review, we provide an overview of four‐membered carbocycles with “emerging” fluorine‐containing motifs, including mono, di, and trifluoromethyl groups, sulfur‐ and other hetero atom‐linked substituents. Such molecular structures are well utilized as one of the recent trends in drug design. Recent progress of cyclobutane‐based polycyclic systems,
Yanai H, Hoshikawa S, Kawai K, Matsumoto T.   +3 more
europepmc   +2 more sources

N-Difluoromethylindazoles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To study the possibility of the N-difluoromethylation and separation of 1-difluoromethyl and 2-difluoromethyl isomers of C-substituted indazoles, as well as some possibilities of functionalization of such molecules. Results and discussion.
Kirill I. Petko, Andrey A. Filatov
doaj   +1 more source

Reagent-Controlled Highly Stereoselective Difluoromethylation: Efficient Access to Chiral α-Difluoromethylamines from Ketimines

Molecules, 2022
A reagent-controlled highly stereoselective reaction between (S)-difluoromethyl phenyl sulfoximine 1 and imines is reported, and this synthetic method provides a variety of enantiomerically enriched α-difluoromethyl amines. The main pros of this approach
Qinghe Liu, Taige Kong, Chuanfa Ni, Jinbo Hu   +3 more
doaj   +1 more source