Results 1 to 10 of about 1,305,955 (360)

Targeted delivery of irinotecan to colon cancer cells using epidermal growth factor receptor-conjugated liposomes

BioMedical Engineering OnLine, 2022
Background CPT-11 (irinotecan) is one of the most efficient agents used for colorectal cancer chemotherapy. However, as for many other chemotherapeutic drugs, how to minimize the side effects of CPT-11 still needs to be thoroughly described.
Yongwei Liu, Xinghui Li, Renqun Pen, Wei Zuo, Ya Chen, Xiuying Sun, Juhua Gou, Qianwen Guo, Maoling Wen, Wuqi Li, Shuangjiang Yu, Hao Liu, Min Huang   +12 more
doaj   +1 more source

Effects of bowel preparation on intestinal bacterial associated urine and faecal metabolites and the associated faecal microbiome

BMC Gastroenterology, 2022
Background Urinary and faecal metabolic profiling have been extensively studied in gastrointestinal diseases as potential diagnostic markers, and to enhance our understanding of the intestinal microbiome in the pathogenesis these conditions.
Sam T. R. Powles, Kate I. Gallagher, Leo W. L. Chong, James L. Alexander, Benjamin H. Mullish, Lucy C. Hicks, Julie A. K. McDonald, Julian R. Marchesi, Horace R. T. Williams, Timothy R. Orchard   +9 more
doaj   +1 more source

FOXQ1-mediated SIRT1 upregulation enhances stemness and radio-resistance of colorectal cancer cells and restores intestinal microbiota function by promoting β-catenin nuclear translocation

Journal of Experimental & Clinical Cancer Research, 2022
Background Resistance of colorectal cancer (CRC) cells to radiotherapy considerably contributes to poor clinical outcomes of CRC patients. Microarray profiling in this study revealed the differentially expressed forkhead box Q1 (FOXQ1) in CRC, and thus ...
Mei Yang, Qian Liu, Maolin Dai, Renqun Peng, Xinghui Li, Wei Zuo, Juhua Gou, Feixue Zhou, Shuangjiang Yu, Hao Liu, Min Huang   +10 more
doaj   +1 more source

A glucagon analogue decreases body weight in mice via signalling in the liver

Scientific Reports, 2021
Glucagon receptor agonists show promise as components of next generation metabolic syndrome pharmacotherapies. However, the biology of glucagon action is complex, controversial, and likely context dependent.
Charlotte E. Hinds, Bryn M. Owen, David C. D. Hope, Philip Pickford, Ben Jones, Tricia M. Tan, James S. Minnion, Stephen R. Bloom   +7 more
doaj   +1 more source

Expression and prognosis analysis of JMJD5 in human cancers

Frontiers in Bioscience-Landmark, 2021
Background: JumonjiC (JmjC) domain-containing protein 5 (JMJD5) plays an important part in cancer metabolism. However, the prognostic value of JMJD5 in most human cancers is unknown yet.
Hui Li, Qun Li, Hong Jing, Jianghai Zhao, Hui Zhang, Xuhui Ma, Lunshou Wei, Rujiang Dai, Weihong Sun, Zhimin Suo   +9 more
doaj   +1 more source

Bioinformatics analysis of ferroptosis-related genes and immune cell infiltration in non-alcoholic fatty liver disease

European Journal of Medical Research, 2023
Background The morbidity and mortality rates of patients with non-alcoholic fatty liver disease (NAFLD) have been steadily increasing in recent years. Previous studies have confirmed the important role of ferroptosis in NAFLD development; however, the ...
Huan Zhang, Malina Axinbai, Yuqing Zhao, Jiaoyang Wei, Tongshuo Qu, Jingmin Kong, Yongqiang He, Liping Zhang   +7 more
doaj   +1 more source

Adherence to the Mediterranean diet and risk of gastric cancer: a systematic review and dose–response meta-analysis

Frontiers in Nutrition, 2023
BackgroundDespite growing evidence for the association of adherence to the Mediterranean diet with gastric cancer risk, the results remain inconclusive.
Qin Zhu, Qin Zhu, Long Shu, Feng Zhou, Li-Peng Chen, Yu-Liang Feng   +5 more
doaj   +1 more source

Telomere elongation protects heart and lung tissue cells from fatal damage in rats exposed to severe hypoxia

Journal of Physiological Anthropology, 2018
Background The effects of acute hypoxia at high altitude on the telomere length of the cells in the heart and lung tissues remain unclear. This study aimed to investigate the change in telomere length of rat heart and lung tissue cells in response to ...
Yaping Wang, Zhen Zhao, Zhiyong Zhu, Pingying Li, Xiaolin Li, Xiaohong Xue, Jie Duo, Yingcai Ma   +7 more
doaj   +1 more source

Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity

Communications Medicine, 2022
Penney et al. conduct microbial and metabolic profiling in people with obesity, with or without type 2 diabetes, undergoing two types of bariatric surgery.
Nicholas C. Penney, Derek K. T. Yeung, Isabel Garcia-Perez, Joram M. Posma, Aleksandra Kopytek, Bethany Garratt, Hutan Ashrafian, Gary Frost, Julian R. Marchesi, Sanjay Purkayastha, Lesley Hoyles, Ara Darzi, Elaine Holmes   +12 more
doaj   +1 more source

Review of Rifaximin: A Summary of the Current Evidence and Benefits Beyond Licensed Use

European Medical Journal, 2021
Antibiotic resistance in patients with cirrhosis continues to draw significant attention. With a propensity to frequent hospitalisations, patients with cirrhosis are subject to frequent antibiotic prescription.
Rooshi Nathwani, Benjamin Mullish, David Kockerling, Alexander Cole, Nowlan Selvapatt, Ameet Dhar   +5 more
doaj   +1 more source