Results 81 to 90 of about 1,305,955 (360)
Rheumatoid arthritis reprograms circadian output pathways
Arthritis Research & Therapy, 2019 Objective We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). Methods We recruited adults (age 16–80 years old) with a clinical diagnosis of RA (active disease [DAS28 > 3.2]).
Toryn M. Poolman +13 more
doaj +1 more source
Potential roles of claudin-3 and claudin-4 in ovarian cancer management
Journal of the Egyptian National Cancer Institute, 2022 Background Ovarian cancer has the highest mortality amongst all gynaecological malignancies, with around two-thirds of patients diagnosed with advanced disease due to late presentation.
Leshanth Uthayanan, Mona El-Bahrawy
doaj +1 more source
On the simulation of enzymatic digest patterns: the fragmentation of oligomeric and polymeric galacturonides by endo-polygalacturonase II [PDF]
arXiv, 2006 A simulation methodology for predicting the time-course of enzymatic digestions is described. The model is based solely on the enzyme's subsite architecture and concomitant binding energies. This allows subsite binding energies to be used to predict the evolution of the relative amounts of different products during the digestion of arbitrary mixtures ...
arxiv
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Animal, 2011 This work aimed to study the response of the growing rabbit caecal ecosystem (bacterial community and caecal environmental parameters) after a switch from a control to a low-fibre diet (LFD). A group of 160 rabbits were fed ad libitum a control diet (ADF:
R.J. Michelland +5 more
doaj
INRAE Productions Animales, 2012 La restriction temporaire de l'ingestion du lapin après son sevrage est maintenant une stratégie d'alimentation couramment employée en cuniculture. L'objet de cette synthèse est de présenter les différents effets d'une limitation de l'ingestion sur la ...
T. GIDENNE +2 more
doaj +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis
Journal for ImmunoTherapy of CancerBackground Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse model to characterize the mechanism of CPI-hepatitis and to therapeutically target ...
Nick Powell +12 more
doaj +1 more source
Frontiers in Nutrition, 2020 The short chain fatty acids (SCFAs) acetate, butyrate and propionate, are produced by fermentation of non-digestible carbohydrates by the gut microbiota and regulate appetite, adiposity, metabolism, glycemic control, and immunity.
Matilda Shackley +6 more
doaj +1 more source
Effect of turbulent diffusion in modeling anaerobic digestion [PDF]
In this study, the impact of turbulent diffusion on mixing of biochemical reaction models is explored by implementing and validating different models. An original codebase called CHAD (Coupled Hydrodynamics and Anaerobic Digestion) is extended to incorporate turbulent diffusion and validate it against results from OpenFOAM with 2D Rayleigh-Taylor ...
arxiv +1 more source