Results 81 to 90 of about 6,490,607 (252)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Digestive enzyme complement of Liza parsia (Hamilton) [PDF]

, 1993
An attempt was made to survey various digestive enzymes present in different regions of the digestive tract of the mullet, Liza parsia. The crude enzyme extracts from the digestive tract could hydrolyse a wide range of carbohydrate substrates.
Palanisamy, K
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Glyphosate on digestive enzymes activity in piava (Leporinus obtusidens)

Ciência Rural, 2014
The effects of glyphosate, a nonselective herbicide (1.0 or 5.0mg L-1) on digestive enzymes activity (stomach and intestine) were evaluated in juveniles of piava (Leporinus obtusidens) after 90 days of exposure.
Joseânia Salbego, Alexandra Pretto, Vera Maria Machado da Silva, Vania Lucia Loro, Rafael Lazzari, Carolina Rosa Gioda, Bernardo Baldisserotto   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Factors Influeucing the Digestive Enzyme Activity of Copepods

, 1994
【中文摘要】 桡足类消化酶活力的影响因子汤鸿，李少菁（厦门大学海洋系，３６１００５）ＦａｃｔｏｒｓＩｎｆｌｕｅｕｃｉｎｇｔｈｅＤｉｇｅｓｔｉｖｅＥｎｚｙｍｅＡｃｔｉｖｉｔｙｏｆＣｏｐｅｐｏｄｓ．￥ＴａｎｇＨｏｎｇ；ＬｉＳｈａｏｃｈｉｎｇ（Ｏ－ｃｅａｎｏｌｏｇｙＤｅ... 【英文摘要】 actors influencing the digestive enzyme activity of copepods are as follows:(1) Food condi-tions:Both ...
李少菁, 汤鸿
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Activity of Solanum tuberosum Leaf Extract and Chaconine in the Gut of Tenebrio molitor Larvae

Toxins
Steroidal glycoalkaloids (GAs) are key plant defense compounds, yet their effects on insect gut physiology are not fully understood. We investigated how purified α-chaconine and Solanum tuberosum leaf extract influence the gut function and growth of the ...
Malgorzata Slocinska, Justyna Mirek, Zbigniew Adamski, Jan Lubawy   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Effects of water temperature on digestive protease activity and apparent nutrient digestibility in Pacific whiteleg shrimp, Litopenaeus vannamei (Boone, 1931)

Aquaculture Reports
Water temperature strongly influences metabolic rate, digestive physiology, and nutrient utilization in poikilothermic aquatic species such as shrimp.
Benjamin Castro, Zlatko Kovac, Pablo Leyton, Alberto Nunes, Carlos Espinoza   +4 more
doaj   +1 more source