Results 51 to 60 of about 17,737,377 (302)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
AUTOIMMUNE DISEASES OF DIGESTIVE SYSTEM
Annals of the Russian academy of medical sciences, 2015 Autoimmune diseases of digestive system refer to pathological conditions, caused by autoimmune mechanisms, and their etiology remains unknown. This is a group of relatively rare diseases, however, during the last years a marked tendency towards the raise in incidence and prevalence is observed, which led to an increase in number of clinical ...
V T, Ivashkinl +8 more
openaire +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
BiomedicinesBackground: In recent years, many studies have attempted to develop models to predict the recurrence of hepatocarcinoma after liver transplantation.
María Martínez Burgos +6 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
ANATOMY OF THE DIGESTIVE SYSTEM IN NEWBORNS
, 2023 This article comprehensively explores the unique anatomy of the digestive system in newborns, shedding light on the structural and functional aspects crucial for early development. From the esophagus to the large intestine, each component is dissected to
Gulomovna, Barno, Komilova, Nodira
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Approaching treatment for immunological rejection of living-donor liver transplantation in rats
BMC Gastroenterology, 2020 Background The anti-immunological rejection therapy for small-for-size syndrome (SFSS) after live donor liver transplantation (LDLT) play a central role in keeping graft survival.
Yanhu Feng +12 more
doaj +1 more source
Digestive system of the snail.
, 2012 (A) Photograph of the African giant snail Achatina fulica. (B) Whole digestive system dissected. The black arrow indicates the crop filled with juice. DNA for the metagenome analysis was extracted from this fluid.
Alexandra L. Gerber (123121) +13 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source