Results 91 to 100 of about 1,714,978 (342)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Use of Medicinal Plants in Digestive System Related Disorders- A Systematic Review

Journal of Ayurvedic and Herbal Medicine, 2021
The most prevalent forms of ailments affecting a huge number of individuals throughout the world are digestive system problems. According to the World Health Organization (WHO), over 100 million people died globally as a result of digestive system ...
H. S. Cheema, Mitra Pal Singh
semanticscholar   +1 more source

Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds [PDF]

, 2017
Background Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features.
Evans, K M, Lewis, T W, Llewellyn-Zaidi, A M, O'Neill, D G, Wiles, B M   +4 more
core   +2 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Early Detection of Oncological Diseases of the Digestive System (Guidelines of the Russian Gastroenterological Association and the Russian Association of Oncologists for Primary Care Physicians)

Russian Journal of Gastroenterology Hepatology Coloproctology, 2019
Aim. The present guidelines intended for primary care physicians are aimed at facilitating early diagnosis of malignant tumours of the digestive system, which can significantly improve the immediate and long-term results of their treatment.General ...
V. T. Ivashkin, I. V. Mayev, A. Kaprin, M. Yu. Agapov, D. N. Andreev, A. S. Vodoleev, M. Zharkova, M. P. Korolev, Yu. A. Kucheryavyi, T. Lapina, M. V. Mayevskaya, A. Okhlobystin, Ch. S. Pavlov, A. V. Paraskevova, S. S. Pirogov, E. Poluektova, D. Rumyantseva, A. Trukhmanov, P. Tsarkov, A. Sheptulin, O. S. Shifrin   +20 more
semanticscholar   +1 more source

A systematic review on application of deep learning in digestive system image processing

The Visual Computer, 2021
With the advent of the big data era, the application of artificial intelligence represented by deep learning in medicine has become a hot topic . In gastroenterology, deep learning has accomplished remarkable accomplishments in endoscopy, imageology, and
Huangming Zhuang, Jixiang Zhang, Fei Liao   +2 more
semanticscholar   +1 more source

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
core  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Digestive diseases of cattle diagnosed at the “Clínica de Bovinos de Garanhuns”-UFRPE: retrospective study and influence of seasonality

Pesquisa Veterinária Brasileira, 2021
: Diseases of the bovine digestive system make up an important group of diseases, often being responsible for significant economic losses in the livestock sector.
Gliére S.L. Soares, Nivaldo A. Costa, José Augusto B. Afonso, Maria I. Souza, Jobson F.P. Cajueiro, Jean C.R. Silva, Fernando Ferreira, Carla L. Mendonça   +7 more
doaj   +1 more source

Diseases of the Digestive System and Air Pollution

The International Annals of Medicine, 2018
Aim: The aim of this work is to study the diseases of the human digestive system in Cyprus and their relationship to smoking and air pollution. Methods: The statistical methods were used to derive the results of this work are Student t-test in order to check the statistical significance of digestive diseases in relation to gender, One-Way ANOVA test ...
Irene Rethemiotaki, Andrew Rethemiotakis
openaire   +2 more sources