Results 71 to 80 of about 508,895 (295)

POSSIBILITYIES OF PHYTOTHERAPY AT DIGESTIVE SYSTEM DISEASES

Фармация и фармакология (Пятигорск), 2016
In the present paper the modern approaches to the reasonable using of phytopharmaceuticals for diseases of gastrointestinal tract were discussed. Substantiates using groups of medicinal plants for the treatment of diseases of gastrointestinal tract based
A. V. Kurkina, V. R. Galyamova, V. A. Kurkin, E. V. Avdeeva   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Treatment of Obesity Through Glial Cell-Derived Neurotrophic Factor Lipid Nanoparticle Delivery in Mice

Gastro Hep Advances
Background and Aims: The overexpression of glial cell-derived neurotrophic factor (GDNF) in the liver and adipose tissues offers strong protection against high-fat diet (HFD)-induced obesity in mice.
Chunhua Yang, Simon Musyoka Mwangi, Arun Balasubramaniam, Ge Li, Olivier Merlin-Zhang, Yunshan Liu, Shanthi Srinivasan   +6 more
doaj   +1 more source

Epidemiology of Inflight Medical Events [PDF]

International Journal of Travel Medicine and Global Health, 2019
Introduction: Since the 1950s, air travel has grown exponentially. In 2018, the number of international air passengers was estimated at 4.1 billion. Air travel exposes the passenger to a number of constraints (like physical constraints, stress) that can ...
Gaetan Guiu, Jonathan Monin, Eric Perrier, Olivier Manen   +3 more
doaj   +1 more source

Effects of chlorhexidine gluconate oral care on hospital mortality : a hospital-wide, observational cohort study [PDF]

, 2018
Chlorhexidine oral care is widely used in critically and non-critically ill hospitalized patients to maintain oral health. We investigated the effect of chlorhexidine oral care on mortality in a general hospitalized population.
Blot, Stijn, Deschepper, Mieke, Eeckloo, Kristof, Vogelaers, Dirk, Waegeman, Willem   +4 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A novel antigenic epitope identified on the accessory protein NS6 of porcine deltacoronavirus

Virus Research
Porcine deltacoronavirus (PDCoV) is a novel enteric coronavirus that can cause vomiting, watery diarrhea in pigs and the death of piglets. The open reading frame (ORF) 5 is one of the accessory genes in PDCoV genome and encodes an accessory protein NS6 ...
Qiuge Liu, Jianxiao Wu, Na Gao, Xiaorong Zhang, Mingze Gao, Xin Zhang, Longjun Guo, Yang Wu, Da Shi, Hongyan Shi, Jianfei Chen, Li Feng   +11 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The parasympathetic and sensory innervation of the proximal and distal colon in male mice

Frontiers in Neuroanatomy
IntroductionThe distributions of extrinsic neurons innervating the colon show differences in experimental animals from humans, including the vagal and spinal parasympathetic innervation to the distal colon.
Lixin Wang, Lixin Wang, Yvette Taché, Yvette Taché   +3 more
doaj   +1 more source