Results 71 to 80 of about 19,447,195 (247)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The views of health care professionals about selective decontamination of the digestive tract : An international, theoretically informed interview study [PDF]

, 2014
Copyright © 2014 Elsevier Inc.
Todd, L., Wells, E. C., Bolsover, D., Prior, M. E., Duncan, Eilidh M., E. Prior, Maria, Webster, F., E. Todd, Laura, Rose, L., H. Cuthbertson, Brian, C. Wells, Elisabeth, Prior, Maria E, Francis, Jill J, Bellingan, Geoff, Marshall, Andrea P, Duncan, Eilidh M, J. Francis, Jill, Todd, Laura E, Campbell, Marion K, Seppelt, I., Prior, Maria E., Rose, Louise, SuDDICU International Study Group, SuDDICU International Study Group, For the, M. Seppelt, Ian, Cuthbertson, Brian H., Newlands, Rumana S, Francis, J., Marshall, Andrea, S. Newlands, Rumana, K. Campbell, Marion, Cuthbertson, B. H., Marshall, A. P., Newlands, R. S., Campbell, M. K., Wells, Elisabeth C, Seppelt, Ian M, Bellingan, G., M. Duncan, Eilidh, Duncan, E. M., Cuthbertson, Brian H, Bolsover, Denise, Webster, Fiona   +42 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of gastrointestinal symptoms and psychological distress on quality of life in systemic sclerosis: a cross-sectional study

BMJ Open
Background Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by microvascular damage and fibrosis. Mortality in patients with SSc has significantly decreased.
Claudia Barber, Ariadna Aguilar, Alfredo Guillén-Del-Castillo, Luis Gerardo Alcala-Gonzalez, Claudia Codina, Antonio Marin Garcia, Carolina Malagelada, Carmen P Simeon-Aznar   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Treatment of Obesity Through Glial Cell-Derived Neurotrophic Factor Lipid Nanoparticle Delivery in Mice

Gastro Hep Advances
Background and Aims: The overexpression of glial cell-derived neurotrophic factor (GDNF) in the liver and adipose tissues offers strong protection against high-fat diet (HFD)-induced obesity in mice.
Chunhua Yang, Simon Musyoka Mwangi, Arun Balasubramaniam, Ge Li, Olivier Merlin-Zhang, Yunshan Liu, Shanthi Srinivasan   +6 more
doaj   +1 more source

POSSIBILITYIES OF PHYTOTHERAPY AT DIGESTIVE SYSTEM DISEASES

Фармация и фармакология (Пятигорск), 2016
In the present paper the modern approaches to the reasonable using of phytopharmaceuticals for diseases of gastrointestinal tract were discussed. Substantiates using groups of medicinal plants for the treatment of diseases of gastrointestinal tract based
A. V. Kurkina, V. R. Galyamova, V. A. Kurkin, E. V. Avdeeva   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Urgent revascularization of a liver allograft with a saphenous vein interposition graft between the hepatic artery and the recipient splenic artery after late hepatic artery thrombosis

, 2005
Digestive Diseases and Sciences, Vol. 50, No. 6 (June 2005), pp. 1177–1180 ( C 2005)Hepatic artery thrombosis (HAT) after liver transplantation is a severe complication which may lead to graft infarction and subsequent graft loss. It complicates 2–12%
Işık, Burak, Söğütlü, Gökhan, Yılmaz, Sezai, Ara, Cengiz, Battaloğlu, Bektaş, Yılmaz, Mehmet, Kıvrımoğlu,Hale S., Kıvrımoğlu, Vedat   +7 more
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