Results 91 to 100 of about 334,417 (282)

Priorities of inpatient internal care in case of chronic digestive system diseases

, 2015
Bakalaura darba “Pacientu aprūpes prioritātes gremošanas sistēmas hronisku saslimšanu gadījumā” mērķis – noskaidrot, aprūpes prioritātes pacientiem ar hroniskām gremošanas sistēmas saslimšanām. Pētījuma izvirzītā hipotēze – aprūpes prioritātes pacientiem
Luškovska, Ņina
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Investigation of porcine circovirus type 2 and porcine circovirus type 3 infections based on dual TaqMan fluorescent quantitative PCR method and genetic evolutionary analysis of these two viruses

Frontiers in Microbiology
IntroductionPorcine circovirus type 2 (PCV2) is the pathogen of Porcine Circovirus Associated Diseases. Porcine circovirus type 3 (PCV3) is a novel porcine circovirus associated with porcine dermatitis and nephropathy syndrome (PDNS) and reproductive ...
Mengxiang Cao, Yanwu Wei, Weilin Shi, Li Feng, Liping Huang   +4 more
doaj   +1 more source

The Main Symptoms and Syndromes in Diseases of the Digestive System

, 2016
The article presents the main clinical symptoms and syndromes that occur in various diseases of the abdominal cavity. Both widely known and rare symptoms of gastroenterological dise­ases are presented.
О.M. Kovalenko, I.N. Kononov, M.V. Chalyi   +2 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Multicomponent Agents for Prevention and Treatment of Digestive Diseases

, 2020
Introduction. In recent years, there has been a steady increase in gastroenterological diseases in many countries due to adverse environmental conditions and unsustainable nutrition.
E. V. Ferubko
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Enfermidades do sistema digestório de bovinos da região semiárida do Brasil

Pesquisa Veterinária Brasileira
RESUMO: Os problemas digestivos são importantes causas de afecções em bovinos e estudos sobre a frequência de ocorrência destas na região semiárida do Brasil ainda não foram realizados.
Ana L.A. Marques, Gildeni M.N. Aguiar, Milena A.A. Lira, Eldinê G. Miranda Neto, Sérgio S. Azevedo, Sara V.D. Simões   +5 more
doaj   +1 more source