Results 51 to 60 of about 1,487,193 (321)

Management of Acute Nonvariceal Upper Gastrointestinal Hemorrhage: Comparison of an American and a Canadian Medical Centre

Canadian Journal of Gastroenterology, 2003
OBJECTIVES: Acute nonvariceal upper gastrointestinal hemorrhage (UGIH) remains a common indication for hospital admission. Differences in the structure, process and outcomes of care in the management of acute nonvariceal UGIH between providers in Canada ...
Laura E Targownik, Ian M Gralnek, Gareth S Dulai, Brennan MR Spiegel, Tommy Oei, Charles N Bernstein   +5 more
doaj   +1 more source

Cytotoxic Activity of Holothuria leucospilota Extract against Leishmania infantum In Vitro

Advances in Pharmacological Sciences, 2016
Leishmaniasis is a tropical parasitic infection. The resistance and toxicity issues are the major complications and remain significant consequences related to the treatment of leishmaniasis with the recent and classical drugs.
Shahram Khademvatan, Alborz Eskandari, Jasem Saki, Masoud Foroutan-Rad   +3 more
doaj   +1 more source

Pathology and physiology of acid-sensitive ion channels in the digestive system (Review)

International Journal of Molecular Medicine, 2022
As a major proton-gated cation channel, acid-sensitive ion channels (ASICs) can perceive large extracellular pH changes. ASICs play an important role in the occurrence and development of diseases of various organs and tissues including in the heart ...
Li Zhang, Liming Zheng, Xingyue Yang, S. Yao, Hui Wang, Jiaxing An, Hai Jin, Guorong Wen, B. Tuo   +8 more
semanticscholar   +1 more source

Dietary Factors in Relation to Helicobacter pylori Infection

Gastroenterology Research and Practice, 2014
Background and Aim. Helicobacter pylori (HP) and diet are both risk factors for gastric cancer. The aim of this study was to evaluate the Helicobacter pylori infection and dietary habits common in Khuzestan province. Methods.
Seyyed Ali Mard, Hossein Khadem Haghighian, Vahid Sebghatulahi, Bijan Ahmadi   +3 more
doaj   +1 more source

Dysbiosis: The first hit for digestive system cancer

Frontiers in Physiology, 2022
Gastrointestinal cancer may be associated with dysbiosis, which is characterized by an alteration of the gut microbiota. Understanding the role of gut microbiota in the development of gastrointestinal cancer is useful for cancer prevention and gut ...
Si Mei, Zhexian Deng, Yating Chen, Di Ning, Yinmei Guo, Xingxing Fan, Ruoyu Wang, Yu-Meng Meng, Qing Zhou, Xuefei Tian   +9 more
semanticscholar   +1 more source

Transduction of Systemically Administered Adeno-Associated Virus in the Colonic Enteric Nervous System and c-Kit Cells of Adult Mice

Frontiers in Neuroanatomy, 2022
Systemic delivery of adeno-associated virus (AAV) vectors transduces the enteric nervous system. However, less is known on the mapping and morphological and neurochemical characterization in the adult mouse colon.
Lixin Wang, Lixin Wang, Pu-Qing Yuan, Pu-Qing Yuan, Collin Challis, Sripriya Ravindra Kumar, Yvette Taché, Yvette Taché   +7 more
doaj   +1 more source

Applications of human organoids in the personalized treatment for digestive diseases

Signal Transduction and Targeted Therapy, 2022
Digestive system diseases arise primarily through the interplay of genetic and environmental influences; there is an urgent need in elucidating the pathogenic mechanisms of these diseases and deploy personalized treatments.
Qinying Wang, Fanying Guo, Yutao Jin, Yanlei Ma   +3 more
semanticscholar   +1 more source

Kaposi's sarcoma-associated herpes virus-derived microRNA K12–1 over-activates the PI3K/Akt pathway to facilitate cancer progression in HIV-related gastrointestinal Kaposi's sarcoma

SLAS Discovery, 2022
Background: Kaposi's sarcoma-associated herpes virus (KSHV) initiate and accelerate the development of Kaposi's sarcoma (KS), and KSHV possesses many cancer-associated genes, including KSHV-derived microRNA miR-K12–1, which has been identified to be ...
Xiaoling Huang, Wei Rao, Chun Wang, Jiajie Lu, Ziqiong Li, Wenjie Kong, Yan Feng, Tian Xu, Rziya Apaer, Feng Gao   +9 more
doaj  

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Cholelithiasis as a possible manifestation of systemic digestive diseases

Terapevticheskii arkhiv, 2015
To comprehensively study of the function of digestive organs in cholelithiasis (CL).Three hundred and seventeen patients with the early (prestone) stage of CL were examined. The latter was verified by ultrasonography (USG) and biochemical bile tests. The patients underwent pH metry and esophagogastroduodenoscopy, followed by histological examination of
M V Lyapina, E. V. Suchkova, N A Khokhlacheva, A Yu Gorbunov, D. V. Tronina, Ya M Vakhrushev   +5 more
openaire   +4 more sources