Results 171 to 180 of about 43,606 (204)

Remote detection of the critical view of safety in pediatric laparoscopic cholecystectomy using artifitial intelligence. [PDF]

World J Pediatr Surg
Olivieri SE, Darrigran S, Petracchi E, Bidone P, Pérez A, Cardozo L, Fernández M, Zandalazini H, Della Pia I.   +8 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Validation of the Institute Mutualiste Montsouris system for the stratification of laparoscopic liver resections: an international multicenter study. [PDF]

Hepatobiliary Surg Nutr
Mazzotta A, Fuks D, Soubrane O, Tan HL, Syn NL, Dokmak S, Gruttadauria S, Cipriani F, Zimmitti G, Alzoubi M, Sugioka A, Scatton O, Herman P, Peng Y, Marino MV, Croner RS, Mazzaferro V, Chiow AKH, Sucandy I, Ivanecz A, Choi SH, Lee JH, Gastaca M, Vivarelli M, Giuliante F, Ruzzenente A, Yong CC, Yin M, Fondevila C, Efanov M, Morise Z, Di Benedetto F, Brustia R, Dalla Valle R, Boggi U, Geller D, Belli A, Memeo R, Mejia A, Park JO, Rotellar F, Choi GH, Robles-Campos R, Hasegawa K, Kawaguchi Y, Wang X, Sutcliffe RP, Pratschke J, Lai ECH, Chong CCN, D'Hondt M, Monden K, Lopez-Ben S, Kingham TP, Liu R, Ferrero A, Ettorre GM, Cherqui D, Liang X, Wakabayashi G, Troisi RI, Cheung TT, Sugimoto M, Han HS, Long TCD, Zhang W, Wei Y, Aghayan DL, Edwin B, Chen KH, Abu Hilal M, Aldrighetti L, Goh BKP, International Robotic and Laparoscopic Liver Resection Study Group Investigators.   +73 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Safety of Recombinant Thrombomodulin for Severe Gastroenterological Sepsis-Induced Coagulopathy in Patients Undergoing Invasive Digestive Procedures: A Single-Center Retrospective Cohort Study. [PDF]

Cureus
Fujikawa T, Nagata K.
europepmc   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

How are duodenal trauma managed? A French nationwide study. [PDF]

World J Emerg Surg
Frey S, Bentellis I, Gaujoux S, Girard E, Abba J, Chirica M, Bertrand M, Boutry E, Mège D, Aubert M, Alves A, Hornez E, Mulliri A, Brustia R, Hentati H, Lauka L, Laurent A, Sommacale D, Turco C, Dezeustre M, Bajul M, Castel A, Facy O, Grellet R, Sulpice L, Ménégaux F, Delestre M, Lermite E, Monchal T, Amrou R, Bacoeur-Ouzillou O, Pezet D, Bonnet J, Buc E, Passot G, Schneck AS, Birnbaum DJ, Blanc PY, Le Roy B, Monneuse O, Rodriguez Q, Suc B, Baqué P, Dubuisson V, Massalou D.   +44 more
europepmc   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Preoperative expiratory muscle training for swallowing function in patients with esophageal cancer undergoing esophagectomy: A randomized controlled phase II trial protocol. [PDF]

PLoS One
Mizusawa H, Noguchi M, Tamura T, Shiraishi M, Kanki K, Shiraishi O, Hiraki Y, Kato H, Higashimoto Y, Yasuda T.   +9 more
europepmc   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source