Results 51 to 60 of about 11,947 (231)

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

eLife, 2015
An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-fate decisions despite sharing the same signalling cascades. Here, we uncovered an unexpected mechanism of RTK trafficking in this process.
Roberto Villaseñor, Hidenori Nonaka, Perla Del Conte-Zerial, Yannis Kalaidzidis, Marino Zerial   +4 more
doaj   +1 more source

Micro-Electro-Mechanical Systems in Light Stabilization

Sensors, 2023
This article discusses application considerations in the micro-electro-mechanical system’s optical sensor. Furthermore, the provided analysis is limited to application issues occurring in research or industrial applications.
Marian Gilewski
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Processing Methods for Digital Image Data Based on the Geographic Information System

Complexity, 2021
Digital image data processing is mainly to input digital image data into a computer to complete the conversion of a continuous spatially distributed image model into a discrete digital model so that the computer can identify, process, and store the ...
Xi Wang, Taizheng Chen, Dongwei Li, Shiqi Yu   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A capacitive mismatch calibration method for SAR ADCs based on TDC

Electronics Letters
The capacitance mismatch problem limits the accuracy improvement of high‐precision SAR ADCs (Successive Approximation Register Analog‐to‐Digital Converters).
Qing Shen, Xin Wang, Mei Jiang, Junxian Chen, Xinhui He, Huanhuan Zhou   +5 more
doaj   +1 more source

Computer Aided Analysis of Turbine Blade Vibration Test Data

Measurement + Control, 1973
A pilot system has been developed which automatically scans and evaluates experimental vibration data obtained from a test rig replica of a bladed wheel of a turbine in service. High vibration amplitude signals are selected for further analysis.
F. L. N-Nagy, S. R. Taylor
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Digitizing UK analogue magnetogram records from large geomagnetic storms of the past two centuries

Geoscience Data Journal, 2023
Continuous geomagnetic records of the strength and direction of the Earth's field at the surface extend back to the 1840s. Over the past two centuries, eight observatories have existed in the United Kingdom, which measured the daily field variations ...
Ciaran D. Beggan, Eliot Eaton, Eleanor Maume, Ellen Clarke, John Williamson, Thomas Humphries   +5 more
doaj   +1 more source