Results 41 to 50 of about 10,492,455 (350)
Nature Materials, 2014 Balancing the complexity and the simplicity has played an important role in the development of many fields in science and engineering. As Albert Einstein was once quoted to say: 'Everything must be made as simple as possible, but not one bit simpler'. The simplicity of an idea brings versatility of that idea into a broader domain, while its complexity ...
Nader Engheta +1 more
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Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
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BMGN - Low Countries Historical Review, 2013 Digital humanities seem to be omnipresent these days and the discipline of history is no exception. This introduction is concerned with the changing practice of ‘doing’ history in the digital age, seen within a broader historical context of developments in the digital humanities and ‘digital history’.
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, 2014 The study of what is collectively labeled New Media —the cultural and artistic practices made possible by digital technology—has become one of the most vibrant areas of scholarly activity and is rapidly turning into an established academic field, with ...
Harris, Katherine D
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Digital humanities, digital methods, digital history, and digital outputs: History writing and the digital revolution [PDF]
History Compass, 2018 AbstractWhile the term “digital humanities” appears inclusive, its exact meaning remains unclear and its early association with studies in English Literature means the term has already been partially superceded by “digital methods.” However, that renaming is problematic as it emphasises the research tools used while the field itself is adjusting to ...
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, 2001 Much of the early work on information theory was directed towards the study of the transmission of telegraph signals. These theoretical treatments lend themselves to descriptions of signals as digital phenomena they are much less convenient for dealing ...
Monk, John
core
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
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