Results 41 to 50 of about 2,282,773 (331)

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

open access: yesMolecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke   +12 more
wiley   +1 more source

Expediente

open access: yesTexto Digital, 2020
Expediente da Revista Texto Digital, v. 16, n. 2, ago./dez. 2020.
Texto Digital
doaj   +2 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Expediente

open access: yesTexto Digital, 2016
Expediente do volume 12 de número 2, 2016.
Texto Digital
doaj   +2 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Digital me ontology and ethics [PDF]

open access: yesarXiv, 2020
This paper addresses ontology and ethics of an AI agent called digital me. We define digital me as autonomous, decision-making, and learning agent, representing an individual and having practically immortal own life. It is assumed that digital me is equipped with the big-five personality model, ensuring that it provides a model of some aspects of a ...
arxiv  

Digital History and the Politics of Digitization

open access: yesDigital Scholarship in the Humanities, 2022
Abstract Much has been made in recent years of the transformative potential of digital resources and historical data for historical research. Historians seem to be flooded with retro-digitized and born-digital materials and tend to take these for granted, grateful for the opportunities they afford.
openaire   +2 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

Digital micrography [PDF]

open access: yesACM Transactions on Graphics, 2011
We present an algorithm for creating digital micrography images, or micrograms , a special type of calligrams created from minuscule text. These attractive text-art works successfully combine beautiful images with readable meaningful text.
Ron Maharik   +4 more
openaire   +6 more sources

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

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