Results 71 to 80 of about 3,012,293 (309)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Meeting report: “Re-thinking/ re-configuring participation”. Conference, 2021 (online)

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2022
Daniela van Geenen, Katharina Kinder-Kurlanda   +1 more
doaj   +1 more source

Ageing Workers and Digital Future

Rivista Trimestrale di Scienza dell'Amministrazione, 2021
The aim of this paper is to understand what the bottlenecks are for ageing workers in relation to technological innovation and how to help them in overcoming it. The paper is structured as follows. After the introduction, the second paragraph is devoted to the state of the art of the topic of the criticalities older workers face in the labour market ...
openaire   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

International lessons for the digital age [PDF]

, 2008
Some commentators hold the view that the digital divide is a problem largely caused by lack of access to appropriate technologies which, when overcome, will act as a virtual panacea for many interlinked ills. Yet, others see this as far too simplistic an
Breen, Paul
core  

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Antropologia culturale, social media, rete: qualche riflessione preliminare

EtnoAntropologia, 2022
In this paper the authors introduce the monographic section on cultural anthropology, social media and web edited by them, presenting some preliminary reflections on these issues in the digital age and discussing briefly the five essays composing the ...
Gaetano Mangiameli, Eugenio Zito
doaj  

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

EXPLORE THE HISTORICAL MATERIALIST PERSPECTIVE ON THE ALIENATION OF LABOUR IN THE CURRENT DIGITAL AGE

Tạp chí Khoa học
This article examines the phenomenon of labour alienation in the digital age from the perspective of historical materialism, taking the contradiction between modern productive forces (Artificial Intelligence - AI, Big Data, automation, and the ...
Nguyen Van Sang
doaj   +1 more source