Results 51 to 60 of about 22,211 (263)
Advanced Science, EarlyView.This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen +15 more
wiley +1 more source
Advanced Science, EarlyView.SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao +15 more
wiley +1 more source
Capture All the URLs: First Steps in Web Archiving
Pennsylvania Libraries: Research & Practice, 2014 As higher education embraces new technologies, university activities—including teaching, learning, and research—increasingly take place on university websites, on university-related social media pages, and elsewhere on the open Web.
Alexis Antracoli +3 more
doaj +1 more source
Advanced Science, EarlyView.We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du +11 more
wiley +1 more source
Annals of the University of Craiova for Journalism, Communication and ManagementThis paper examines the critical issue of digital content preservation in modern journalism, focusing on the imperative of personal digital archiving practices among journalists.
Dan Valeriu VOINEA
doaj
Bausteine ForschungsdatenmanagementThe article presents how a textual corpus can be deposited in a data repository for digital archiving purposes. It discusses which metadata standards and file formats should be used.
Francesco Gelati
doaj +1 more source
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Advanced Science, EarlyView.Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, EarlyView.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source
Legal Deposit of Digital Materials
Liber Quarterly: The Journal of European Research Libraries, 2003 Digital publishing is causing a real paradigm shift for research institutions and publishers, as well as for libraries. As a consequence these institutions have to develop new policies, new business models and new infrastructures and techniques.
Erik Oltmans
doaj +1 more source