Results 51 to 60 of about 1,101,363 (264)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The collections concept at the University of Sheffield: a varied approach to the role of research library collections

Insights: The UKSG Journal
This article discusses the development of the Library collections concept at the University of Sheffield. It draws together several wider themes of collection management and seeks to conceive of library content as serving differing functions through ...
Peter Barr
doaj   +1 more source

DiViDu – An Open Source Solution for Dual Task Experiments with Integrated Divided Visual Field Paradigm

Journal of Open Research Software, 2018
We here present DiViDu, a research software, which we developed for a dual task experiment with an integrated divided visual field paradigm. The dual task experiment consists of a lexical decision task with different semantic verb categories, and a ...
Nina Heck, Moritz Schubotz
doaj   +1 more source

Experimental Study for Determining the Parameters Required for Detecting ECG and EEG Related Diseases during the Timed-Up and Go Test

Computers, 2020
The use of smartphones, coupled with different sensors, makes it an attractive solution for measuring different physical and physiological features, allowing for the monitoring of various parameters and even identifying some diseases. The BITalino device
Vasco Ponciano, Ivan Miguel Pires, Fernando Reinaldo Ribeiro, María Vanessa Villasana, Maria Canavarro Teixeira, Eftim Zdravevski   +5 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

How and When? Metacognition and Solution Timing Characterize an “Aha” Experience of Object Recognition in Hidden Figures

Frontiers in Psychology, 2019
The metacognitive feelings of an “aha!” experience are key to comprehending human subjective experience. However, behavioral characteristics of this introspective cognition are not well known.
Tetsuo Ishikawa, Mayumi Toshima, Ken Mogi   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A Reuse Evaluation for Solar-Cell Silicon Wafers via Shift Revolution and Tool Rotation Using Magnetic Assistance in Ultrasonic Electrochemical Micromachining

International Journal of Photoenergy, 2013
A new reuse fabrication using a tool module with rotation and revolution through a process of magnetic assistance in ultrasonic electrochemical micromachining (UEMM) for removal of the surface layers from silicon wafers of solar cells is demonstrated ...
P. S. Pa
doaj   +1 more source

Lessons Learned from Data Management Activities after the Great East Japan Earthquake in March 2011

Data Science Journal, 2013
This paper summarizes our effort towards managing the multi-disciplinary disaster-related data from the Great East Japan Earthquake, which happened on March 11, 2011 off the coast of Northeast Japan.
A Kitamoto
doaj   +1 more source