Results 71 to 80 of about 1,385,411 (314)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Stripe-Transformer: deep stripe feature learning for music source separation

EURASIP Journal on Audio, Speech, and Music Processing, 2023
Music source separation (MSS) is to isolate musical instrument signals from the given music mixture. Stripes widely exist in music spectrograms, which potentially indicate high-level music information. For example, a vertical stripe indicates a drum time
Jiale Qian, Xinlu Liu, Yi Yu, Wei Li
doaj   +1 more source

Creating Digital Content for the Individual Learner: A Personalized Approach to Online Learning

, 2021
Online learning programs are becoming more and more popular; however, they are challenged with creating digital content catered to individual students’ needs and interests (Ziphorah, 2014). The concept of personalized learning is not new but advancements
McCurley, Genna Sengstacke
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The collections concept at the University of Sheffield: a varied approach to the role of research library collections

Insights: The UKSG Journal
This article discusses the development of the Library collections concept at the University of Sheffield. It draws together several wider themes of collection management and seeks to conceive of library content as serving differing functions through ...
Peter Barr
doaj   +1 more source

DiViDu – An Open Source Solution for Dual Task Experiments with Integrated Divided Visual Field Paradigm

Journal of Open Research Software, 2018
We here present DiViDu, a research software, which we developed for a dual task experiment with an integrated divided visual field paradigm. The dual task experiment consists of a lexical decision task with different semantic verb categories, and a ...
Nina Heck, Moritz Schubotz
doaj   +1 more source

Experimental Study for Determining the Parameters Required for Detecting ECG and EEG Related Diseases during the Timed-Up and Go Test

Computers, 2020
The use of smartphones, coupled with different sensors, makes it an attractive solution for measuring different physical and physiological features, allowing for the monitoring of various parameters and even identifying some diseases. The BITalino device
Vasco Ponciano, Ivan Miguel Pires, Fernando Reinaldo Ribeiro, María Vanessa Villasana, Maria Canavarro Teixeira, Eftim Zdravevski   +5 more
doaj   +1 more source

METHODOLOGY OF DIGITAL CONTENT CREATION

Advanced Information Systems
The subject of the study is the individualization of the learning process in the process of assimilating information with different levels of subjective complexity. The purpose of the study is to develop a methodology for creating digital content to manage student behavior by changing the objective complexity of the learning material.
Serkov, Oleksandr, Kasilov, Oleg, Voronets, Vitalii, Trubchaninova, Karyna, Churyumov, Gennady   +4 more
openaire   +2 more sources

Some economics of digital content [PDF]

, 2005
The music industry is currently subject to changes influenced by ongoing digitalisation and informatization that are unprecedented. Other sectors can expect to undergo in the near future what the media industry is going through now – the movie industry being a prime suspect.
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source