Results 51 to 60 of about 1,846,658 (288)
Open source repositories: Implications for libraries [PDF]
, 2010 Software that is accepted as “Open source” should comply with 10 conditions which are itinerated in the paper. The paper subsequently describes the application of open source initiatives in the digital library context.
A.N., Zainab
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Frontiers in PsychiatryIntroductionPathological gaming continues to be highlighted as one of the most critical issues concerning adolescents. Numerous studies have aimed to elucidate the relationships between adolescents' negative emotions (e.g., peer stress, anxiety ...
Sung Je Lee +3 more
doaj +1 more source
Frontiers in Psychology, 2023 IntroductionGame cheating (i.e., behavior of violating rules in games by using unregulated Software or assistive devices to gain advantage) poses a fatal problem as it destroys fair competition systems and negatively impacts the game ecosystem.
Sung Je Lee +3 more
doaj +1 more source
Editors’ Introduction: Approaching the online audience: new practices, new thinking [PDF]
, 2011 Convergence culture, participatory culture, user generated content, interactive media; these are all now familiar terms within contemporary media and communication studies that have risen to distinguish emergent content across digital platforms and ...
Athique, Adrian M. +3 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in PsychologyIntroductionLong-term exposure to negative emotions (e. g., anxiety, depression, loneliness) in adolescents has been reported to inhibit psychological growth and contribute to academic stress, aggression, and problem behaviors, including pathological ...
Jeong Ae Kim +3 more
doaj +1 more source
Research Notes on the Emerging Concepts of Digital Heritage in Brazil [PDF]
, 2010 This paper presents the first results in our investigation of the emerging Digital Heritage concepts in Brazil. It focuses on the analysis of a government experience with social media intended to prepare an official report on digital culture.
Dantas, Camila Guimaraes, Dodebei, Vera
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Frontiers in PsychologyIntroductionAs adolescent pathological gaming is increasingly recognized as a societal issue, previous research has aimed to identify the effects of family-related factors (e.g., parenting attitudes, parent–child relationship, etc.) and adolescents ...
Jae In Choi +3 more
doaj +1 more source