Results 31 to 40 of about 818,441 (263)

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Soft Interventions

open access: yesTahiti, 2021
Recently there has been a growing number of artists working between photography and digital art, creating artworks in which the signs of digital operations have been left visible.
Jane Vuorinen
doaj   +1 more source

A rationale of digital documentary editions [PDF]

open access: yesLiterary and Linguistic Computing, 2011
Publishing the diplomatic edition of a document on the web instead of in print implies a series of methodological and practical changes in the nature of the published text and in the operations to be performed by the editors. For print the choice of which features to include in the transcription is limited largely by the limits of the publishing ...
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Digital Scholarly Editing

open access: yes, 2016
This volume presents the state of the art in digital scholarly editing. Drawing together the work of established and emerging researchers, it gives pause at a crucial moment in the history of technology in order to offer a sustained reflection on the practices involved in producing, editing and reading digital scholarly editions—and the theories that
Driscoll, Matthew James, Pierazzo, Elena
openaire   +5 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Peran Media Digital dalam Meningkatkan Branding Desa Wisata

open access: yesNajwa, 2023
Digital Marketing merupakan hal yang dilakukan untuk meningkatkan penjualan produk sebuah brand atau merek. Tujuan dari kegiatan pelatihan ini adalah untuk meningkatkan kesadaran Desa Bulusari, khususnya Dusun Sawur, sebagai desa wisata melalui Digital ...
Muhammad Nabil Khasbulloh   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Critical approaches to ‘clerical’ work: Textual transmission in two Swedish digital resources

open access: yesLiber Quarterly: The Journal of European Research Libraries, 2019
In this paper, we investigate the distinction between library digitization projects and digital scholarly editing projects by using qualitative interview data gathered from two Swedish digital scholarship ecosystems: 1) Litterarturbanken (the Swedish ...
Merisa Martinez
doaj   +1 more source

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