Results 41 to 50 of about 38,354,375 (294)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Digital Scholarly Editing

, 2016
This volume presents the state of the art in digital scholarly editing. Drawing together the work of established and emerging researchers, it gives pause at a crucial moment in the history of technology in order to offer a sustained reflection on the practices involved in producing, editing and reading digital scholarly editions—and the theories that
Driscoll, Matthew James, Pierazzo, Elena
openaire   +5 more sources

Peran Media Digital dalam Meningkatkan Branding Desa Wisata

Najwa, 2023
Digital Marketing merupakan hal yang dilakukan untuk meningkatkan penjualan produk sebuah brand atau merek. Tujuan dari kegiatan pelatihan ini adalah untuk meningkatkan kesadaran Desa Bulusari, khususnya Dusun Sawur, sebagai desa wisata melalui Digital ...
Muhammad Nabil Khasbulloh, Latifah Bela, Irma Niawati, Ahsanul Huda, Nexsa Kirara Jeaqulien   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A rationale of digital documentary editions [PDF]

Literary and Linguistic Computing, 2011
Publishing the diplomatic edition of a document on the web instead of in print implies a series of methodological and practical changes in the nature of the published text and in the operations to be performed by the editors. For print the choice of which features to include in the transcription is limited largely by the limits of the publishing ...
openaire   +3 more sources

Critical approaches to ‘clerical’ work: Textual transmission in two Swedish digital resources

Liber Quarterly: The Journal of European Research Libraries, 2019
In this paper, we investigate the distinction between library digitization projects and digital scholarly editing projects by using qualitative interview data gathered from two Swedish digital scholarship ecosystems: 1) Litterarturbanken (the Swedish ...
Merisa Martinez
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Alternative splicing and extensive RNA editing of human TPH2 transcripts. [PDF]

, 2010
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT.
Bondy, Brigitta, Bondy, B., Baghai Thomas C., Brigitta Bondy, Peter Zill, Zill, P., Schüle Cornelius, Hammer, P., Grohmann Maik, Büttner, A., Walther Maria, Priller, Josef, Hammer Paul, Baghai, Thomas C., Maik Grohmann, Wolfgang Eisenmenger, Baghai, T., Priller Josef, Josef Priller, Walther, D.J., Eisenmenger, Wolfgang, Bader, Michael, Zill, Peter, Paul Hammer, Hammer, Paul, Rupprecht Rainer, Büttner, Andreas, Michael Bader, Andreas Büttner, Diego J Walther, Cornelius Schüle, Paulmann, Nils, Zill Peter, Bader Michael, Eisenmenger, W., Schüle, Cornelius, Maria Walther, Rainer Rupprecht, Thomas C Baghai, Paulmann Nils, Schuele, C., Walther, Diego J., Rupprecht, R., Nils Paulmann, Baghai, T.C., Eisenmenger Wolfgang, Walther, Maria, Grohmann, M., Bondy Brigitta, Walther Diego J., Bader, M., Priller, J., Paulmann, N., Büttner Andreas, Walther, M., Grohmann, Maik, Rupprecht, Rainer, Schüle, C., Walther, D., Buettner, A.   +59 more
core   +1 more source

Jane Austen’s Fiction Manuscripts

RIDE, 2017
Jane Austen’s Fiction Manuscripts Digital Edition (JAFM), edited by Kathryn Sutherland, provides high-resolution pages images and diplomatic transcriptions for all of Austen’s surviving fiction manuscripts (totalling approximately 1100 manuscript pages),
Michelle Levy
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source