Results 41 to 50 of about 1,023,750 (299)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Peran Media Digital dalam Meningkatkan Branding Desa Wisata

open access: yesNajwa, 2023
Digital Marketing merupakan hal yang dilakukan untuk meningkatkan penjualan produk sebuah brand atau merek. Tujuan dari kegiatan pelatihan ini adalah untuk meningkatkan kesadaran Desa Bulusari, khususnya Dusun Sawur, sebagai desa wisata melalui Digital ...
Muhammad Nabil Khasbulloh   +4 more
doaj   +1 more source

Encoding models for scholarly literature [PDF]

open access: yes, 2009
We examine the issue of digital formats for document encoding, archiving and publishing, through the specific example of "born-digital" scholarly journal articles.
Holmes, Martin, Romary, Laurent
core   +5 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

A rationale of digital documentary editions [PDF]

open access: yesLiterary and Linguistic Computing, 2011
Publishing the diplomatic edition of a document on the web instead of in print implies a series of methodological and practical changes in the nature of the published text and in the operations to be performed by the editors. For print the choice of which features to include in the transcription is limited largely by the limits of the publishing ...
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

The Print and Digital Editions of Lyn Hejinian’s My Life

open access: yesTransatlantica
My Life by Lyn Hejinian is now regarded as an exemplary work of the Language movement. It exists in several editions: first published in 1980, it was amended in 1987.
Chloé Thomas
doaj   +1 more source

Digital Editing of Early Modern English Handwritten Texts: Handling Scribal Errors and Corrections [PDF]

open access: yes, 2017
An important philological question is how to edit texts. An edition always entails interpretation of the text and also of the socio-cultural context in which the manuscript was created and used.
Esteban-Segura, Laura
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Critical approaches to ‘clerical’ work: Textual transmission in two Swedish digital resources

open access: yesLiber Quarterly: The Journal of European Research Libraries, 2019
In this paper, we investigate the distinction between library digitization projects and digital scholarly editing projects by using qualitative interview data gathered from two Swedish digital scholarship ecosystems: 1) Litterarturbanken (the Swedish ...
Merisa Martinez
doaj   +1 more source

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