Results 41 to 50 of about 818,441 (263)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Jane Austen’s Fiction Manuscripts
RIDE, 2017 Jane Austen’s Fiction Manuscripts Digital Edition (JAFM), edited by Kathryn Sutherland, provides high-resolution pages images and diplomatic transcriptions for all of Austen’s surviving fiction manuscripts (totalling approximately 1100 manuscript pages),
Michelle Levy
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Семантическое издание текстов Л. Н. Толстого: от текста к онтологии
Napis, 2018 The article presents the results of a digital editing project devoted to Leo Tolstoy’s The Collected Works, developed as an open access material. Our main source is the ninety-volume critical edition of Leo Tolstoy’s texts.
Анастасия Бонч-Осмоловская +4 more
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Notes from the Front: Resisting Maximalism in Your Minimal Edition
Journal of the Text Encoding InitiativeMinimal editions have become popular because they address the problem of curating texts under a set of constraints—practical, conceptual, technical, and editorial.
Francesca Giannetti
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dlaczego polskie edytorstwo naukowe nie istnieje
Teksty Drugie, 2016 This article addresses the condition of scholarly editing in Poland, projecting the development that could occur thanks to the use of digital tools. Bem demands an evaluation of the editorial tradition and the concepts and categories of classification ...
Paweł Bem
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source