Results 61 to 70 of about 621,841 (302)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Digital Chaucer pedagogy and editing: probing generative AI’s reproduction of hegemony [PDF]
This paper contributes insight to discussions around the use of generative AI in digital pedagogical editing, and the challenges these technologies present when empowering students to uncover, and recognise the erasure of, marginalised voices in medieval
Whittle, S.
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Семантическое издание текстов Л. Н. Толстого: от текста к онтологии
Napis, 2018 The article presents the results of a digital editing project devoted to Leo Tolstoy’s The Collected Works, developed as an open access material. Our main source is the ninety-volume critical edition of Leo Tolstoy’s texts.
Анастасия Бонч-Осмоловская +4 more
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dlaczego polskie edytorstwo naukowe nie istnieje
Teksty Drugie, 2016 This article addresses the condition of scholarly editing in Poland, projecting the development that could occur thanks to the use of digital tools. Bem demands an evaluation of the editorial tradition and the concepts and categories of classification ...
Paweł Bem
doaj
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Employ digital editing (non-consecutive) in enriching the filming of expression
الأستاذ, 2017 Find boils down to is marked by (employing digital editing (non-consecutive) in enriching Filma expression), and the reflection of the digital montage to the enrichment of the movie film.
Dr. Najeeb Asleawa Haidoo
doaj +1 more source