Results 51 to 60 of about 1,023,750 (299)

A Revision Control System for Image Editing in Collaborative Multimedia Design

open access: yes, 2018
Revision control is a vital component in the collaborative development of artifacts such as software code and multimedia. While revision control has been widely deployed for text files, very few attempts to control the versioning of binary files can be ...
Calefato, Fabio   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Jane Austen’s Fiction Manuscripts

open access: yesRIDE, 2017
Jane Austen’s Fiction Manuscripts Digital Edition (JAFM), edited by Kathryn Sutherland, provides high-resolution pages images and diplomatic transcriptions for all of Austen’s surviving fiction manuscripts (totalling approximately 1100 manuscript pages),
Michelle Levy
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Notes from the Front: Resisting Maximalism in Your Minimal Edition

open access: yesJournal of the Text Encoding Initiative
Minimal editions have become popular because they address the problem of curating texts under a set of constraints—practical, conceptual, technical, and editorial.
Francesca Giannetti
doaj   +1 more source

Embodied memory and curatorship in children’s digital video production [PDF]

open access: yes, 2010
Digital video production in schools is often theorised, researched and written about in two ways: either as a part of media studies practice or as a technological innovation, bringing new, “creative”, digital tools into the curriculum.
Potter, John
core   +2 more sources

Refining our Concept of ‘Access’ for Digital Scholarly Editions: A DiXiT Panel on Accessibility, Usability, Pedagogy, Collaboration, Community and Diversity [PDF]

open access: yes, 2017
The Digital Scholarly Editions Initial Training Network (DiXiT) is a Marie Sk odowska-Curie EU-Funded 7th Framework Programme. During the grant period (2013- 2017), twelve Early Stage Research Fellows and five Experi- enced Research Fellows engage with ...
Bleeker, Elli   +5 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Ler, editar, escrever: simulação literária e humanidades digitais

open access: yesTexto Digital, 2022
Resenha de: PORTELA, Manuel. Literary Simulation and the Digital Humanities: Reading, Editing, Writing. New York: Bloomsbury, 2022.
Diego Giménez
doaj   +1 more source

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