Results 51 to 60 of about 38,354,375 (294)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Frame-Based Editing: Combining the Best of Blocks and Text Programming [PDF]

, 2016
Editing program code as text has several major weaknesses: syntax errors (such as mismatched braces) interrupt programmer flow and make automated tool support harder, boilerplate code templates have to be typed out, and programmers are responsible for ...
Neil C. C. Brown, Michael Kolling, Kölling, Michael; id_orcid, Brown, Neil C.C., Amjad Altadmri, Brown, Neil Cc C.; id_orcid, Altadmri, Amjad, Kölling, Michael   +7 more
core   +1 more source

On Editing and the Digitial

, 2015
Editing is tenacious; it barricades itself in the particularity of contexts and disciplines. Nevertheless, it imposes a certain duration to the process of (re)writing; it pauses that which is already articulated, be it in the form of an intervention, a ...
Damian Martin, Diana
core   +1 more source

Семантическое издание текстов Л. Н. Толстого: от текста к онтологии

Napis, 2018
The article presents the results of a digital editing project devoted to Leo Tolstoy’s The Collected Works, developed as an open access material. Our main source is the ninety-volume critical edition of Leo Tolstoy’s texts.
Анастасия Бонч-Осмоловская, Матвей Колбасов, Борис Орехов, Ирина Павлова, Даниил Скоринкин   +4 more
doaj  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Dlaczego polskie edytorstwo naukowe nie istnieje

Teksty Drugie, 2016
This article addresses the condition of scholarly editing in Poland, projecting the development that could occur thanks to the use of digital tools. Bem demands an evaluation of the editorial tradition and the concepts and categories of classification ...
Paweł Bem
doaj  

Notes from the Front: Resisting Maximalism in Your Minimal Edition

Journal of the Text Encoding Initiative
Minimal editions have become popular because they address the problem of curating texts under a set of constraints—practical, conceptual, technical, and editorial.
Francesca Giannetti
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Visualising the Catalogues of Digital Editions

The Journal of Electronic Publishing
This article provides a data-driven overview of the developments in the field of digital scholarly editing. It surveys and evaluates the available data source on digital scholarly editions and provides longitudinal analysis of changes in number of projects, geographic distribution, licensing, interfaces and preservation. Digital scholarly editions (DSE)
Michael Kurzmeier, James O'Sullivan, Mike Pidd, Orla Murphy, Bridgette Wessels   +4 more
openaire   +3 more sources