Results 91 to 100 of about 3,975 (291)

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Predictors for Digital Game Addiction Among Turkish Adolescents

Journal of Addictions Nursing, 2019
Abstract Background: Digital game addiction among adolescents is a growing problem. The purpose of this study is to describe the predictors for this addiction in a group of Turkish adolescents using a conceptual framework.
Irmak, Aylin Yalcin, Erdogan, Semra
openaire   +3 more sources

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

The Relationship Between Digital Game Addiction and Loneliness and Social Dissatisfaction in Adolescents. [PDF]

Cureus, 2023
Parlak ME, Öz E, Ener D, Kurt F, Küçükkelepçe O, Kapıcı Y.   +5 more
europepmc   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Dampak Digital Game Terhadap Perkembangan Sosial Budaya Masyarakat

ANDHARUPA: Jurnal Desain Komunikasi Visual & Multimedia, 2018
Abstrak Sejarah panjang perkembangan game menjadi digital game saat ini ikut membawa perkembangan di berbagai lini kehidupan manusia. Jika dahulu game hanya dikenal sebagai media hiburan dalam waktu luang, kini digital game telah menjadi sebuah ...
Henry Bastian, Khamadi Khamadi
doaj   +1 more source

EXAMINING THE EFFECT OF DIGITAL GAME ADDICTION ON LIFE SATISFACTION: DIGITAL GAMES PROVIDE EMOTIONAL SATISFACTION TO PLAYERS

Electronic Journal of New Media, 2017
Teknolojinin gelişmesi ve teknolojik cihazlara erişimin kolaylaşmasıyla birlikte çoğunluğu gençler ve genç yetişkinlerden oluşan geniş bir kitlenin dijital oyunlara yoğun ilgisinin olduğu görülmektedir. Dijital oyunlar, kişisel bilgisayarlar; oyun konsolları ya da cep telefonları olmak üzere birçok farklı teknolojik cihaz aracılığıyla oynanabilmektedir.
Öksüz, Yunus Emre, Masatcıoğlu, Gözde   +1 more
openaire   +2 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Investigation into Emotional Intelligence, Social and Emotional Loneliness and Digital Game Addictions of Mid-Adolescent Students

Research in Sport Education and Sciences
The research was conducted to examine the emotional intelligence, social and emotional loneliness and digital game addictions of secondary school students.
Bahar Güler
doaj   +1 more source