Results 121 to 130 of about 705,935 (306)

Dataspill og metode: en samtale med Espen Aarseth og Torill Mortensen

open access: yesNorsk Medietidsskrift, 2021
Espen Aarseth, Torill Elvira Mortensen
doaj   +1 more source

Digital New Zealand 2014 [PDF]

open access: yes
This report presents data on the lifestyles, habits, attitudes and demographics of New Zealanders who play computer and video games, as well as how New Zealanders are consuming interactive games in conjunction with other digital technologies. The report
Jeffrey E. Brand   +2 more
core  

Digital impact, crossover technologies and gambling practices [PDF]

open access: yes, 2008
At this juncture it is instructive to review the convergent media forms as a starting point for a wider debate about the pervasiveness of games technologies and gambling practices. In particular, to focus upon convergences between gambling and gaming and
Griffiths, MD
core  

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang   +9 more
wiley   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang   +11 more
wiley   +1 more source

Inclusive Digital Gaming Platform

open access: yesMultimedia
The lack of accessibility in digital gaming platforms remains a significant barrier to equitable user participation. To address this issue, this article presents an inclusive solution developed as a multimedia project designed to promote access to digital games for any user through the ipcb.games platform.
Mendonça, Rodrigo   +4 more
openaire   +2 more sources

There's No Place Like Home: Dwelling and Being at Home in Digital Games [PDF]

open access: yes, 2019
This chapter considers the presence, in digital games, of experiences of dwelling. Starting with an engagement with the philosopher Edward S. Casey's distinction between hestial and hermetic spatial modes, the chapter argues that the player's spatial ...
Vella, Daniel
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Emotional involvement in digital games

open access: yesInternational Journal of Arts and Technology, 2011
Digital games have become a pervasive aspect of the contemporary media landscape, yet our understanding of the way they engage players is limited. Experiential studies of games have the added complexity of plugging human consciousness in the cybernetic circuit that generates game–play.
openaire   +2 more sources

Toys for Boys? Women's Marginalization and Participation As Digital Gamers [PDF]

open access: yes
This paper develops out of ongoing research into the location and use of digital gaming in practices of everyday life. Specifically this paper draws on a questionnaire based survey of just under four hundred undergraduate students and twenty-three follow
Garry Crawford, Victoria K. Gosling
core  

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