Results 41 to 50 of about 425,474 (289)

The inhibitory SAPS3–AMPK interaction detected in HEK293 cells is not detectable in muscle or liver from humans or mice

open access: yesFEBS Letters, EarlyView.
This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk   +3 more
wiley   +1 more source

Evolutionary Subject Tagging in the Humanities; Supporting Discovery and Examination in Digital Cultural Landscapes [PDF]

open access: yes, 2011
In this paper, the authors attempt to identify problematic issues for subject tagging in the humanities, particularly those associated with information objects in digital formats.
Ammerman, Jack   +3 more
core   +1 more source

Present, Not Voting: Digital Humanities in the Panopticon: Closing Plenary Speech, Digital Humanities 2010 [PDF]

open access: yes, 2010
Digital Humanities faces many issues in the current financial and educational climate. In this closing plenary from the Digital Humanities conference 2010 at King’s College London, major concerns about the current role and function of Digital Humanities ...
TERRAS, M
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Digital Humanities and Librarians: A Team-Based Approach to Learning [PDF]

open access: yes, 2015
This chapter details the development and implementation of an Introduction to Digital Humanities course (ENGL 695) at Kansas State University (K-State).
Crosby, Mark, Hoeve, Casey, Pankl, Lis
core   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Lecture: Getting from here to there

open access: yesMedieKultur: Journal of Media and Communication Research, 2014
Based on his keynote lecture at the international conference on Digital Humanities at Aalborg University in April 2014, John Naughton refl ects on being an engineer in a Humanities research institute that is currently seeking to adapt to the digital ...
John Naughton
doaj   +3 more sources

Corpus Linguistics and Digital Humanities. Intersecting Paths. A Case Study from Twitter

open access: yesAmérica Crítica, 2020
In this paper I aim at critically discussing the role of Corpus Linguistics within the field of Digital Humanities. I posit that the accessible and user-friendly tools of Corpus Linguistics are an optimal resource for scholars within the Humanities and ...
Angela Zottola
doaj   +1 more source

Art History and the Digital Humanities: [PDF]

open access: yes, 2016
Invited response to "Hubertus Kohle, "Kunstgeschichte und Digital Humanities. Einladung zu einer Debatte/Art History and the Digital Humanities.
Max Marmor
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

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