Results 61 to 70 of about 23,235 (228)
Who's afraid of Patterns?: The Particular versus the Universal and the Meaning of Humanities 3.0
BMGN: Low Countries Historical Review, 2013 The advent of Digital Humanities has enabled scholars to identify previously unknown patterns in the arts and letters; but the notion of pattern has also been subject to debate.
Rens Bod
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
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GraphEidos: A Dataset of Visual Rhetoric in Digital Humanities
Journal of Open Humanities DataThis data article introduces GraphEidos, a new open-access dataset that documents how visuals have been used and discussed in digital humanities (DH) journal publications. The dataset covers various forms of visual representations, their captions, and in-
Rongqian Ma, Kai Li, Ranvir Singh Virk
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Interdisciplinary Collaboration in Studying Newspaper Materiality
Digital Humanities in the Nordic and Baltic Countries Publications, 2019 This paper presents a collaboration between computer scientists, linguists and historians studying the material aspects of newspapers and developing a tool for that purpose.
Eetu Mäkelä +5 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Annotation of subtitle paraphrases using a new web tool
Digital Humanities in the Nordic and Baltic Countries Publications, 2019 This paper analyzes the manual annotation effort carried out to produce Opusparcus, the Open Subtitles Paraphrase Corpus for six European languages. Within the scope of the project, a new web-based annotation tool was created.
Mikko Aulamo +2 more
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