Results 71 to 80 of about 436,970 (323)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Introduction: Digital Humanities, Public Humanities
NANO, 2014 NANO: New American Notes Online: An Interdisciplinary Academic Journal for Big Ideas in a Small World. This special issue shows how both public and digital humanities research can be rendered more persuasive through engagement with cultures beyond the ...
Alex Christie +3 more
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Digital Public Humanities [PDF]
, 2017 Syllabus for graduate-level course in Digital Public Humanities taught by Jim McGrath (postdoctoral fellow in Digital Public Humanities). Course is part of Brown's Public Humanities M.A.
Jim McGrath
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
o-bib. Das offene Bibliotheksjournal, 2017 Der Beitrag geht von der Beobachtung aus, dass Bibliotheken bisher zwar die Themen E‑Science und Forschungsdaten in ihre Überlegungen hinsichtlich spezifischer Angebote zur Informationskompetenz einbezogen haben. Aber obwohl Bibliotheken über ein breites
Marcus Schröter
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Lecture: Getting from here to there
MedieKultur: Journal of Media and Communication Research, 2014 Based on his keynote lecture at the international conference on Digital Humanities at Aalborg University in April 2014, John Naughton refl ects on being an engineer in a Humanities research institute that is currently seeking to adapt to the digital ...
John Naughton
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Information seeking in the Humanities: physicality and digitality [PDF]
, 2008 This paper presents a brief overview of a research project that is examining the information seeking practices of humanities scholars. The results of this project are being used to develop digital resources to better support these work activities ...
Blandford, A. +4 more
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Visualization in digital humanities
大数据, 2022 The development of information technology has promoted the generation of a new scientific research paradigm.Social sciences and humanities have gradually developed a data-driven research method in recent years.From the perspective of visualization, the ...
Yuchu LUO +6 more
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