Results 71 to 80 of about 425,474 (289)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Who's afraid of Patterns?: The Particular versus the Universal and the Meaning of Humanities 3.0
BMGN: Low Countries Historical Review, 2013 The advent of Digital Humanities has enabled scholars to identify previously unknown patterns in the arts and letters; but the notion of pattern has also been subject to debate.
Rens Bod
doaj +1 more source
A map of Digital Humanities research across bibliographic data sources [PDF]
, 2022 Gianmarco Spinaci +2 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
GraphEidos: A Dataset of Visual Rhetoric in Digital Humanities
Journal of Open Humanities DataThis data article introduces GraphEidos, a new open-access dataset that documents how visuals have been used and discussed in digital humanities (DH) journal publications. The dataset covers various forms of visual representations, their captions, and in-
Rongqian Ma, Kai Li, Ranvir Singh Virk
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Digital Sandbox: Playing with Public Humanities [PDF]
, 2014 poster abstractWe developed and led a daylong workshop on the digital humanities that took place at IUPUI on August 15, 2013. This project grew out of a spring 2013 digital humanities course taught by Dr.
Crosby, Christine +3 more
core
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Digital Humanities and networked digital media
MedieKultur: Journal of Media and Communication Research, 2014 This article discusses digital humanities and the growing diversity of digital media, digital materials and digital methods. The first section describes the humanities computing tradition formed around the interpretation of computation as a rule-based ...
Niels Ole Finnemann
doaj +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source