Results 51 to 60 of about 2,680,690 (272)
Pixel-Bit, 2023 Digital exclusion is a challenging phenomenon in many countries. The low level of digital and media competences among senior citizens raises many questions about the effectiveness of existing digital inclusion activities.
Lukasz Tomczyk +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Behavioral SciencesGrief reactions among relatives of palliative care patients are often overlooked, with most interventions targeting Prolonged Grief Disorder (PGD) rather than its prevention. Few interventions have been developed for individuals at risk. This study aimed
David Dias Neto +4 more
doaj +1 more source
A conceptual study of the factors influencing e-inclusion [PDF]
, 2011 With the advancement of the Internet and supporting Information and Communication Technologies, e-inclusion has emerged as an effective means to create opportunities for all and to further individual autonomy and capability in terms of using online ...
Almuwil, A +2 more
core
Assembling and enriching digital library collections [PDF]
, 2003 People who create digital libraries need to gather together the raw material, add metadata as necessary, and design and build new collections. This paper sets out the requirements for these tasks and describes a new tool that supports them interactively,
Bainbridge, David +2 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Understanding Farmer preferences through citizen Science: Insights on potato varieties in Nigeria
Journal of Agriculture and Food ResearchConventional top-down potato breeding often overlooks farmer input, leading to varieties that may not be suited to local conditions, limiting their adoption and impact on smallholder farming.
K. Sharma +5 more
doaj +1 more source
Doing Digital Inclusion : Health Handbook [PDF]
, 2017 12.6 million UK adults lack basic digital skills and 5.9 million have never used the internet before. People who do not use the internet, in comparison to those who don’t, tend to be older, poorer, and more likely to be disabled.
Morrison, Ciarán, Rooney, Laura
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source