Results 41 to 50 of about 1,358 (264)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

FPGA-Based Implementation of All-Digital QPSK Carrier Recovery Loop Combining Costas Loop and Maximum Likelihood Frequency Estimator

open access: yesInternational Journal of Reconfigurable Computing, 2014
This paper presents an efficient all digital carrier recovery loop (ADCRL) for quadrature phase shift keying (QPSK). The ADCRL combines classic closed-loop carrier recovery circuit, all digital Costas loop (ADCOL), with frequency feedward loop, maximum ...
Kaiyu Wang   +4 more
doaj   +1 more source

A Ka-Band Balanced Four-Beam Phased-Array Receiver With Symmetrical Beam-Distribution Network in 65-nm CMOS

open access: yesIEEE Access, 2021
This paper demonstrates a Ka-band CMOS phased-array receiver capable of generating four balanced beams from two inputs. A passive four-beam symmetrical differential network is proposed to distribute two input signals to eight channels and facilitate beam
Na Peng, Peng Gu, Dixian Zhao
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

A 24 GHz Waveguide based Radar System using an Advanced Algorithm for I/Q Offset Cancelation [PDF]

open access: yesAdvances in Radio Science, 2017
Precise position measurement with micrometer accuracy plays an important role in modern industrial applications. Herewith, a guided wave Six-Port interferometric radar system is presented.
C. Will   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

1.4 GHz Low-Cost PIN Diode Phase Shifter for ${L}$ -Band Radiometer Antenna

open access: yesIEEE Access, 2019
A 1.4 GHz 4-bit positive intrinsic negative (PIN) diode phase shifter with compact reflective loads for an L-band soil moisture measuring radiometer phased array antenna has been successfully designed.
Kim Tuyen Trinh   +3 more
doaj   +1 more source

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