Results 51 to 60 of about 567,904 (289)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Modelling long term digital preservation costs: a scientific data case study [PDF]

, 2013
In recent years there has been increasing UK Government pressure on publicly funded researchers to plan the preservation and ensure the accessibility of their data for the long term. A critical challenge in implementing a digital preservation strategy is
Badawy, Mohamed, Baguley, Paul, Conway, Esther, Lefort, Alice, Shehab, Essam, Turner, Christopher, Wilson, Michael   +6 more
core  

LIBER's involvement in supporting digital preservation in member libraries [PDF]

, 2009
Digital curation and preservation represent new challenges for universities. LIBER has invested considerable effort to engage with the new agendas of digital preservation and digital curation.
Ayris, P.
core   +3 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Reflections on preserving the state of new media art [PDF]

, 2010
As part of its work to explore emerging issues associated with characterisation of digital materials, Planets has explored vocabularies and information structures for expressing the properties integral to the value of digital art.
Barr, M., Konstantelos, L., McHugh, A.
core  

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

LIFE: Costing the digital preservation lifecycle [PDF]

, 2007
Having confidence in the permanence of a digital resource requires a deep understanding of the preservation activities that will need to be performed throughout its lifetime, and an ability to plan and resource for those activities.
Ayris, Paul, Davies, Richard, McLeod, Rory, Shenton, Helen, Wheatley, Paul   +4 more
core  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Política arquivística de preservação digital: um estudo sobre sua aplicabilidade em instituições públicas federais

Perspectivas em Ciência da Informação
Resumo O presente artigo apresenta parte dos resultados obtidos em uma pesquisa de mestrado sobre a preservação do patrimônio documental arquivístico da Federação Espírita do Grande do Sul (FERGS), desenvolvida no Programa de Pós-Graduação Profissional ...
William Silva, Daniel Flores
doaj   +1 more source

Challenges and opportunities in the evolving digital preservation landscape: reflections from Portico

Insights: The UKSG Journal, 2018
There has been tremendous growth in the amount of digital content created by libraries, publishers, cultural institutions and the general public. While there are great benefits to having content available in digital form, digital objects can be extremely
Kate Wittenberg, Sarah Glasser, Amy Kirchhoff, Sheila Morrissey, Stephanie Orphan   +4 more
doaj   +1 more source