Results 61 to 70 of about 269,061 (300)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

The National Digital Information Infrastructure and Preservation Program (NDIIPP) and its Implications for a Research Agenda for Digital Preservation [PDF]

open access: yes, 2002
Legislation enacted by the U.S. Congress in December 2000 allocates funding to the Library of Congress to lead the National Digital Information Infrastructure and Preservation Program (NDIIPP). The collaborative initiative is focused on materials created
Campbell, Laura
core  

Política arquivística de preservação digital: um estudo sobre sua aplicabilidade em instituições públicas federais

open access: yesPerspectivas em Ciência da Informação
Resumo O presente artigo apresenta parte dos resultados obtidos em uma pesquisa de mestrado sobre a preservação do patrimônio documental arquivístico da Federação Espírita do Grande do Sul (FERGS), desenvolvida no Programa de Pós-Graduação Profissional ...
William Silva, Daniel Flores
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

A way forward for development in the digital preservation functions of DSpace: options, issues and recommendations. [PDF]

open access: yes, 2003
This report aims to inform the discussion of the MIT and Cambridge DSpace teams and invited digital preservation experts, meeting on the 30th July, 2003.
Paul Wheatley, P. W.
core  

Trustworthy 100-Year Digital Objects: Evidence Even After Every Witness is Dead [PDF]

open access: yes, 2003
How can a publisher store digital information so that any reader can reliably test its authenticity, even years later when no witness can vouch for its validity?
Gladney, H.M.
core   +1 more source

Challenges and opportunities in the evolving digital preservation landscape: reflections from Portico

open access: yesInsights: The UKSG Journal, 2018
There has been tremendous growth in the amount of digital content created by libraries, publishers, cultural institutions and the general public. While there are great benefits to having content available in digital form, digital objects can be extremely
Kate Wittenberg   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Digital curation and long-term digital preservation in libraries

open access: yesJLIS.it
For over twenty years public institutions and foundations committed in cultural heritage curation and preservation worked up methodologies, strategies and techniques for long-term digital preservation of digital resources. Thanks to a relevant number of
Valdo Pasqui
doaj   +1 more source

Introduction to Digital Preservation

open access: yes, 2017
Introduction to digital preservation for PASIG 2017 Oxford Bootcamp Day on 11 September 2017.
openaire   +1 more source

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