Results 81 to 90 of about 262,813 (297)
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han +8 more
wiley +1 more source
Digital preservation in the context of institutional repositories
, 2006 Type of paper: General review Purpose of this paper: To discuss the issues and challenges of digital preservation facing institutional repositories and to illustrate JISC’s view on institutional repositories and its key initiatives in helping UK ...
Hockx-Yu, Helen
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Trustworthy 100-Year Digital Objects: Durable Encoding for When It's Too Late to Ask
, 2004 How can an author store digital information so that it will be reliably intelligible, even years later when he is no longer available to answer questions?
Gladney, H.M.
core +1 more source
Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan +14 more
wiley +1 more source
BlogForever D3.1: Preservation Strategy [PDF]
, 2013 This report describes preservation planning approaches and strategies recommended by the BlogForever project as a core component of a weblog repository design.
Arango-Docio +9 more
core +1 more source
Digital preservation: challenges and implementation [PDF]
Learned Publishing, 2008 ABSTRACTThe research of the future requires access to the research of the past. This access cannot be assured without reliable long‐term preservation of scholarly digital content. Near‐term access can be guaranteed with backup and access system redundancy. Mid‐term access can be protected with byte replication.
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
QEMU - A Crucial Building Block in Digital Preservation Strategies
, 2011 Emulation as long-term preservation strategy depends on usable, reliable and sustainable emulators to preserve old or obsolete original digital environments.
Rechert, Klaus +2 more
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Introdução à preservação digital : conceitos, estratégias e actuais consensos [PDF]
, 2006 This book aims at describing and contextualizing the main activities carried out internationally in the past 10 years in the field of digital preservation.
Ferreira, Miguel
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