Results 61 to 70 of about 2,520,884 (309)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Digital Theology: Is the Resurrection Virtual? [PDF]
, 2012 Many recent writers have developed a rich system of theological concepts inspired by computers. This is digital theology. Digital theology shares many elements of its eschatology with Christian post-millenarianism.
Steinhart, Eric
core
Trusty URIs: Verifiable, Immutable, and Permanent Digital Artifacts for Linked Data [PDF]
, 2014 To make digital resources on the web verifiable, immutable, and permanent, we propose a technique to include cryptographic hash values in URIs. We call them trusty URIs and we show how they can be used for approaches like nanopublications to make not ...
A. Callahan +12 more
core +4 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
„Digital complete denture – reference protocol“
International Dental JournalINTRODUCTION: The conventional process of fabricating complete dentures consists of 5 to 6 clinical and laboratory phases, which involve multiple visits of edentulous patients to the dental office. Additionally, in the conventional process of fabrication, there are mechanical weaknesses of the acrylic, technological deficiencies of compression-molding ...
Robert Ćelić +3 more
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
ADAPTIVE CROSSING NUMBERS AND THEIR APPLICATION TO BINARY DOWNSAMPLING
Image Analysis and Stereology, 2011 A downsampling method for binary images is presented, which aims at preserving the topology of the image. It uses a general reference sampling structure.
Etienne Decencière, Michel Bilodeau
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Remote Sensing, 2013 The fraction of absorbed photosynthetically active radiation (FPAR) is a key parameter in describing the exchange of fluxes of energy, mass and momentum between the surface and atmosphere.
Quanjun Jiao +3 more
doaj +1 more source