Results 41 to 50 of about 40,231,902 (292)

Digital Receiver Design for Transmitted Reference Ultra-Wideband Systems

EURASIP Journal on Wireless Communications and Networking, 2009
A complete detection, channel estimation, synchronization, and equalization scheme for a transmitted reference (TR) ultra-wideband (UWB) system is proposed in this paper.
Wang Yiyin, Leus Geert, van der Veen Alle-Jan   +2 more
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

INSPIRE from the JRC Point of View

Kartografija i Geoinformacije, 2012
This paper summarises some recent developments in INSPIRE implementation from the JRC (Joint Research Centre) point of view. The INSPIRE process started around 11 years ago and today, clear results and benefits can be seen.
Vlado Cetl, Katalin Tóth, Paul Smits
doaj  

A digital platform for automated analysis of 1H NMR data: prototype framework of digital reference standard

AAPS Open
This study introduces an innovative approach to automatically analyzing 1H nuclear magnetic resonance (NMR) data, integrating a quantum mechanical spectral analysis (QMSA) to enhance efficiency over manual data analysis in NMR.
Sunil Babu Paudel, Joo-Won Nam, Gonzalo R. Malca Garcia, Ben Shapiro, Pekka Laatikainen, Yang Liu   +5 more
doaj   +1 more source

Square wave reference digital lock-in detection using non-orthogonal demodulation

Heliyon, 2023
Digital lock-in detection technique is commonly used to measure the amplitude and phase of a selected frequency signal. The technique which uses a square wave as the reference signal has an advantage of easier implementation and higher computational ...
Miao Li, Yue Sun, Zhen Liang, Shengzhao Zhang   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Advanced strategies for detecting acid sphingomyelinase deficiency type B with attenuated phenotypes

Orphanet Journal of Rare Diseases
Background Acid Sphingomyelinase Deficiency (ASMD) type B is a rare lysosomal disorder caused by SMPD1 mutations. Due to its low prevalence and clinical heterogeneity, diagnosis is challenging, and detection is crucial for the initiation of enzyme ...
Thomas Villeneuve, Thibaut Jamme, Robin Schwob, Thierry Levade, Grégoire Prévot   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

TwinArch: A digital twin reference architecture

Journal of Systems and Software
Submitted for reviewing to The Journal of Systems and ...
Alessandra Somma, Domenico Amalfitano, Alessandra De Benedictis, Patrizio Pelliccione   +3 more
openaire   +3 more sources