Results 31 to 40 of about 732,027 (261)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The digital reference research agenda
Journal of the American Society for Information Science and Technology, 2003 AbstractA research agenda for the study of digital reference is presented. The agenda stems from a research symposium held at Harvard University, Boston, Massachusetts in August 2002. The agenda defines digital reference as “the use of human intermediation to answer questions in a digital environment.” The agenda also proposes the central research ...
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Digital Receiver Design for Transmitted Reference Ultra-Wideband Systems
EURASIP Journal on Wireless Communications and Networking, 2009 A complete detection, channel estimation, synchronization, and equalization scheme for a transmitted reference (TR) ultra-wideband (UWB) system is proposed in this paper.
Wang Yiyin +2 more
doaj +2 more sources
A high - precision measurement chain for reference purposes
Measurement: Sensors, 2021 Reference transducers not only for high pressure (GPa) but also for high force (MN) and high torque (MN▪m) have been based on foil-type strain gauges for decades, due to their excellent signal-to-noise ratio and established, well-proven technology. Thus,
André Schaefer
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
INSPIRE from the JRC Point of View
Kartografija i Geoinformacije, 2012 This paper summarises some recent developments in INSPIRE implementation from the JRC (Joint Research Centre) point of view. The INSPIRE process started around 11 years ago and today, clear results and benefits can be seen.
Vlado Cetl, Katalin Tóth, Paul Smits
doaj
AAPS OpenThis study introduces an innovative approach to automatically analyzing 1H nuclear magnetic resonance (NMR) data, integrating a quantum mechanical spectral analysis (QMSA) to enhance efficiency over manual data analysis in NMR.
Sunil Babu Paudel +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source