Results 51 to 60 of about 1,233,556 (275)

Benefit sharing on genetic resources: Modelling data access, control and willingness‐to‐pay for digital sequence information

Ecological Solutions and Evidence
Fair and equitable sharing of benefits derived from access to genetic resources is central to international agreements and conventions regarding the management of biodiversity.
Tim Coltman, Maui Hudson, Jason Mika, Yvonne Matthews, Jane Anderson, Natalie Kusabs, KatieLee Riddle, Jacob Golan   +7 more
doaj   +1 more source

Mass spectrometry sequencing of long digital polymers facilitated by programmed inter-byte fragmentation

Nature Communications, 2017
Digital information can be stored in monomer sequences of non-natural macromolecules, but only short chains can be read. Here the authors show long multi-byte digital polymers sequenced in a moderate resolution mass spectrometer.
Abdelaziz Al Ouahabi, Jean-Arthur Amalian, Laurence Charles, Jean-François Lutz   +3 more
doaj   +1 more source

Capacity Building Workshop on Genetic Resource Policies for CGIAR Scientists and Partners in East Africa, 4 - 7 June 2019, ILRI Campus, Addis Ababa, Ethiopia [PDF]

, 2020
The CGIAR Genebank Platform Policy Module, in coordination with the International Livestock Research Institute (ILRI), organized the ‘Capacity building workshop on genetic resource policies for CGIAR scientists and partners in East Africa’.
CGIAR Genebank Platform
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Uses and benefits of digital sequence information from plant genetic resources: Lessons learnt from botanical collections

Plants, People, Planet, 2022
Societal Impact Statement Digitized molecular data are vital to numerous aspects of scientific research and genetic resource use. The Convention on Biological Diversity currently refers to this as “Digital Sequence Information” (DSI), a term not widely ...
Carly Cowell, Alan Paton, James S. Borrell, China Williams, Paul Wilkin, Alexandre Antonelli, William J. Baker, Richard Buggs, Michael F. Fay, Roberta Gargiulo, Olwen M. Grace, Benedikt G. Kuhnhäuser, Yannick Woudstra, Paul J. Kersey   +13 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The promise of access and benefit-sharing is met through holistic policy reform: Insights from Colombia’s genetic diversity and innovation landscape during COP16

Genetic Resources
To tackle the global biotechnological innovation divide, Parties to the Convention on Biological Diversity (CBD) are negotiating policies to fairly share the benefits from the use of digital sequence information (DSI) on genetic resources.
Bob Kreiken, Lotte Asveld
doaj   +1 more source

Steganographic method based on hidden messages embedding into Bezier curves of SVG images

Журнал Белорусского государственного университета: Математика, информатика, 2021
The description of the steganographic method for embedding the digital watermark into image vector files of the SVG format is given. Vector images in SVG format can include elements based on Bezier curves.
Evgeniya A. Blinova, Pavel P. Urbanovich   +1 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source