Results 121 to 130 of about 5,961,169 (319)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2012 The ability to demonstrate digital literacy skills, defined by the European Commission as the confident and critical use of ICT for work, leisure, learning and communication, is a key requirement for graduates, demanded both by the UK Quality Assurance ...
Baker, Kirsty, Hall, Marion, Nix, Ingrid
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Studying Academic Lawyers' Information-Seeking to Inform the Design of Digital Law Libraries [PDF]
, 2006 We report findings from the initial phase of our study on legal information seeking, which comprised a series of semi-structured interviews and naturalistic observations of academic law students and staff looking for electronic legal information.
Makri, S.
core +1 more source
Evaluation of Use of Consortium of e-Resources in Agriculture in Context of Kerala Agricultural University [PDF]
, 2012 As digital information resources available online are increasing at an exponential rate, several practices have evolved for the economic and effective delivery of such information to the end users.
Francis, A.T.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Digital skills and digital citizenship education: An analysis based on structural equation modeling
Journal of Technology and Science EducationThe main objective of this study is to examine the correlation between digital skills and their correlation with digital citizenship among students enrolled at a university in Peru.
Olger Gutiérrez-Aguilar +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Creencias de los estudiantes en torno a los Espacios Virtuales de Aprendizaje en el desarrollo de la competencia comunicativa oral. Un estudio de caso [PDF]
, 2019 Oral communicative competence is traditionally neglected in the development of competence of students in compulsory education. In a highly demanding social and professional context, we must contribute to communication skills in general and to oral skills
Corpas Martos, Alberto +1 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source