Results 41 to 50 of about 57,904,552 (254)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Spatially Regularized Fusion of Multiresolution Digital Surface Models [PDF]
IEEE Transactions on Geoscience and Remote Sensing, 2017 In this paper, we propose an algorithm for robustly fusing digital surface models (DSMs) with different ground sampling distances and confidences, using explicit surface priors to obtain locally smooth surface models. Robust fusion of the DSMs is achieved by minimizing the L1-distance of each pixel of the solution to each input DSM.
Kuschk, Georg +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
ISPRS International Journal of Geo-Information, 2019 In this study, different in-situ and close-range sensing surveying techniques were compared based on the spatial differences of the resultant datasets.
Huseyin Yurtseven
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Digital Surface Modelling by Airborne Laser Scanning and Digital Photogrammetry for Glacier Monitoring [PDF]
The Photogrammetric Record, 2001 The research described in this paper is part of a Swiss National Science Foundation project on ”Mass Balance Determination of Glaciers with the Use of State‐of‐the‐art Remote Sensing Methods and a Numerical Flow Model”. The remote sensing methods involve automated processing of aerial images and laser scanning and aim to produce glacier surface models ...
Baltsavias, Emmanuel P. +4 more
openaire +2 more sources
Evaluation of selected methods for extracting digital terrain models from satellite born digital surface models in urban areas [PDF]
, 2011 For the generation of 3D city models from satellite stereo imagery beyond the generation of digital surface models (DSM) from stereo data the next crucial step is the separation of urban 3D objects from ground.
Arefi, Hossein +2 more
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