Results 71 to 80 of about 32,563 (195)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

DIGITAL INSTITUTES OF KNOWLEDGE AND INFORMATION SYSTEMS MANAGEMENT IN SUPPORT OF HIGH-TECH PRODUCTION IN INDUSTRY 4.0 [PDF]

Proceedings on Engineering Sciences
This paper considers the current problems of knowledge and information systems management, which are solved with the help of digital institutes for the purpose of the development of high-tech production in the conditions of Industry 4.0.
Ilmidin T. Yormatov , Nurzhan D. Kenzhebekov , Abdumalik M. Kadirov , Maria G. Umnova   +3 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Survey on the Application of Robotics in Archaeology

Sensors
This work explores the application of robotic systems in archaeology, highlighting their transformative role in excavation, documentation, and the preservation of cultural heritage.
Panagiota Kyriakoulia, Anastasios Kazolias, Dimitrios Konidaris, Panagiotis Kokkinos   +3 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Scaling Logic Area With Multitier Standard Cells

IEEE Journal on Exploratory Solid-State Computational Devices and Circuits
While the footprint of digital complementary metal-oxide–semiconductor (CMOS) circuits has continued to decrease over the years, physical limitations for further intralayer geometric scaling become apparent.
Florian Freye, Christian Lanius, Hossein Hashemi Shadmehri, Diana Gohringer, Tobias Gemmeke   +4 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Systematic Construction of Semantic Structure Computationally Digital Communication Systems As A Model

The Journal of Studies in Language, Culture and Society
Our study deals with the systematic construction of the structural representation of meaning, as it is based on a basic topic, which is structure, as it goes beyond the representation of meaning for its parts, as logical representations are usually used
Aida Haouchi
doaj  

Bias in Machine Learning: A Literature Review

Applied Sciences
Bias could be defined as the tendency to be in favor or against a person or a group, thus promoting unfairness. In computer science, bias is called algorithmic or artificial intelligence (i.e., AI) and can be described as the tendency to showcase ...
Konstantinos Mavrogiorgos, Athanasios Kiourtis, Argyro Mavrogiorgou, Andreas Menychtas, Dimosthenis Kyriazis   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source