Results 91 to 100 of about 450,796 (317)

Digital Transformation Roadmap - Template 10 Change Proposal [PDF]

, 2023
Digital Transformation ...
Petersen, I, Davids, M
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

How to effectively plan for digital transformation [PDF]

, 2023
Enterprise digital transformation is the compelling, emerging strategic imperative of our time. The 4th Industrial Revolution – the confluence of ubiquitous digital access, low-cost sensing enabled by the Internet of Things, advances in artificial ...
Donaldson, William
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Implementation of a digital coordination centre in a hospital: a qualitative evaluation of enablers, barriers and strategies

BMC Health Services Research
Background Digital Coordination Centres (DCCs) represent an innovative approach in hospital settings, designed to enhance patient flow, operational efficiency, and real-time decision-making.
Louise Shaw, Sam Freeman, Sarah Aranha, Adam Boulton, Daniel Capurro, Wendy Chapman, Tim Fazio, Jana Gazarek, Meredith Layton, Kayley Lyons, Sam Plumb, Brad Astbury   +11 more
doaj   +1 more source

Optimization of Ceramic Refractory Materials for Impact Pads in Tundish Systems for Continuous Steel Casting [PDF]

Archives of Metallurgy and Materials
Increasing demands on cast steel quality and the need to reduce carbon footprint drive the development of new refractory materials. A ceramic composition was developed for spherical tundish impact pads to ensure dimensional stability and resistance to ...
B. Buľko, P. Demeter, I. Priesol, L. Fogaráš, S. Hubatka, M. Hrubovčáková, P. Šmigura, D. Dubec   +7 more
doaj   +1 more source

Digital Transformation of the Health Sector in Latin America and the Caribbean [PDF]

, 2019
Digital transformation improves the quality and efficiency of healthcare through the collection of information and its suitable use in decision-making at all levels of the health system.
Inter-American Development Bank
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Diverging motives for inter-municipal digital transformation [PDF]

This paper addresses diverging collaborating motives for digital transformation in an inter-municipal collaboration experiencing difficulties in transitioning from IT-centric to digitally-driven collaboration.
Andersson, Thomas, Silfversparre, Jonna
core   +2 more sources

Vox Populi, Vox ChatGPT: Large Language Models, Education and Democracy

Philosophies
In the era of generative AI and specifically large language models (LLMs), exemplified by ChatGPT, the intersection of artificial intelligence and human reasoning has become a focal point of global attention.
Niina Zuber, Jan Gogoll
doaj   +1 more source