Results 71 to 80 of about 450,796 (317)

Digital Transformation in Renewable Energy: Use Cases and Experiences from a Nordic Power Producer [PDF]

, 2022
The electric power system is changing. The changes include the integration of renewable resources, such as wind farms and solar plants, making the grid smarter so that it can react and adapt to changes and increase customer engagement.
Xing, Liyuan, Sizov, Gleb Valerjevich, Gundersen, Odd Erik   +2 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

schlably: A Python framework for deep reinforcement learning based scheduling experiments

SoftwareX, 2023
Research on deep reinforcement learning (DRL) based production scheduling (PS) has gained a lot of attention in recent years, primarily due to the high demand for optimizing scheduling problems in diverse industry settings.
Constantin Waubert de Puiseau, Jannik Peters, Christian Dörpelkus, Hasan Tercan, Tobias Meisen   +4 more
doaj   +1 more source

Digital transformation and internationalization: how digital transformation affects internationalization strategies of SMEs [PDF]

, 2022
The aim of this research is to investigate the role of digital transformation in the internationalization strategy of small and medium enterprises (SMEs).
Micoli, Stefania
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Advancing cell therapy manufacturing: an image-based solution for accurate confluency estimation

Frontiers in Bioengineering and Biotechnology
Cell therapies represent a transformative approach for treating diseases resistant to conventional therapies, yet their development and manufacturing face significant hurdles within the biopharmaceutical sector.
John Mason, Martin Kraft, Jakob Hueckels, Hao Wei, Konstantinos Spetsieris   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis of the current status and future vision of innovation in a tertiary hospital in Catalonia: a cross-sectional study

BMC Health Services Research
Background Innovation in healthcare is a complex process involving the creation or modification of products, services, or processes, and their successful implementation in clinical settings. University Hospital Germans Trias i Pujol (HUGTP) implemented a
Mireia Cano, Eloi Querol Carranza, Gerard Albreda, Laura Ricou, Oriol Estrada, Daniel Moreno-Martinez   +5 more
doaj   +1 more source

Transformation of Digital Ecosystems: The Case of Digital Payments [PDF]

, 2014
In digital ecosystems, the fusion relation between business and technology means that the decision of technical compatibility of the offering is also the decision of how to position the firm relative to the coopetive relations that characterize business ecosystems.
Henningsson, Stefan, Hedman, Jonas
openaire   +1 more source

Digital transformation of healthcare facility management services [PDF]

The ongoing digital disruption is reshaping the healthcare system, including medical and care services, as well as the non-medical supportservices of which facility management (FM) is part of.
Schmitter, Paul
core   +1 more source