Results 81 to 90 of about 450,796 (317)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Applying Decision Transformers to Enhance Neural Local Search on the Job Shop Scheduling Problem

AI
Background: The job shop scheduling problem (JSSP) and its solution algorithms have been of enduring interest in both academia and industry for decades.
Constantin Waubert de Puiseau, Fabian Wolz, Merlin Montag, Jannik Peters, Hasan Tercan, Tobias Meisen   +5 more
doaj   +1 more source

The Interplay of Digital Transformational Leadership, Organizational Agility, and Digital Transformation

Journal of the Knowledge Economy, 2023
The rules of the game are changing in organizations due to several digital advances, ecosystems, industries, and fields. Also, the emergence of new institutional infrastructures and complex systems during this period can result in digital transformation (DT).
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Enablers for coordination of digital transformation in international manufacturing networks [PDF]

, 2021
The digital transformation of International Manufacturing Networks (IMNs) has been identified as a complex undertaking that requires coordination. However, knowledge about coordination in this context is lacking.
Bruch, Jessica,, Granlund, Anna,, Ahlskog, Mats,, Badasjane, Viktoria,   +3 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Exploring Barriers, Enablers, and Strategies for Implementing Learning Health System Projects in Healthcare Organizations: A Multilevel Analysis in an Australian Setting

Learning Health Systems
Objective To analyze the barriers, enablers, and strategies affecting the implementation of learning health systems (LHS) projects across individual (micro), organizational (meso), and system (macro) levels within Australian healthcare settings Methods ...
Louise Shaw, Meg Perrier, Kayley Lyons, Mikayla Wolfe, Rahul Barmanray, Daniel Capurro, Wendy Chapman, Sathana Dushyanthen   +7 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Transforming document management for environmental sustainability: the mediating effect of pro-environmental culture and service satisfaction in higher education institutions

Frontiers in Sustainability
This research investigates the factors influencing environmental sustainability in a Peruvian higher education institution (HEI), using Structural Equation Modeling (SEM) with SmartPLS.
Jessie Bravo, Carlos Valdivia, Roger Alarcón, Nilton Germán, Oscar Serquén, Janet Aquino, Marco Agustín Arbulú Ballesteros, Laurita Guevara   +7 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source