Results 81 to 90 of about 1,473,665 (331)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Vox Populi, Vox ChatGPT: Large Language Models, Education and Democracy

Philosophies
In the era of generative AI and specifically large language models (LLMs), exemplified by ChatGPT, the intersection of artificial intelligence and human reasoning has become a focal point of global attention.
Niina Zuber, Jan Gogoll
doaj   +1 more source

NASA's Digital Transformation (DT) Initiative [PDF]

NASA's Digital Transformation (DT) Initiative will dramatically enhance NASA's mission impact by reinventing mission and mission support processes, products, and capabilities, enabled by an innovation culture, digital-savvy workforce, and advanced ...
Barthelemy, J.-F., Biegel, Bryan
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Optimizing Virtual Power Plants with Parallel Simulated Annealing on High-Performance Computing

Smart Cities
This work focuses on optimizing the scheduling of virtual power plants (VPPs)—as implemented in the Portuguese national project New Generation Storage (NGS)—to maximize social welfare and enhance energy trading efficiency within modern energy grids.
Ali Abbasi, Filipe Alves, Rui A. Ribeiro, João L. Sobral, Ricardo Rodrigues   +4 more
doaj   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

UI/UX design requirements for young stroke survivors: recommendations from the literature

npj Digital Medicine
There is currently no single resource for UI/UX guidelines and design standards that encapsulates all the requirements for young stroke survivors (
Deborah Passey, Hasan Ferdous, Kara Burns, Cecily Gilbert, Emma Power, Tanya Rose, Julie Bernhardt, Vincent Thijs, Daniel Capurro   +8 more
doaj   +1 more source

Impact of digital transformation: assessing the knowledge and adoption of disruptive technologies in a higher education institution

Frontiers in Computer Science
Digital transformation has become a key factor for educational development since it not only involves the integration of disruptive technologies but also the restructuring of the process and cultural adaptation that allows Higher Education Institutions ...
Janet Aquino, Roger Alarcón, Laurita Guevara, Jessie Bravo-Jaico, Nilton Germán, Carlos Valdivia-Salazar, Oscar Serquén, Gisella Luisa Elena Maquen-Niño, Alfonso Tesén-Arroyo   +8 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Knowledge Transformation and Economic Development: The Role of Digital Technology- An Analysis [PDF]

This paper assesses the role of evolutionary process in knowledge transformation and economic development, especially due to emerging diversified digital technology.
Alam, Adnan, Herani, Gobind M., Rajar, Allah Wasayo, Zaman, Noor   +3 more
core   +1 more source