Results 81 to 90 of about 42,176,970 (357)

Advancing cell therapy manufacturing: an image-based solution for accurate confluency estimation

Frontiers in Bioengineering and Biotechnology
Cell therapies represent a transformative approach for treating diseases resistant to conventional therapies, yet their development and manufacturing face significant hurdles within the biopharmaceutical sector.
John Mason, Martin Kraft, Jakob Hueckels, Hao Wei, Konstantinos Spetsieris   +4 more
doaj   +1 more source

Transformation of Digital Ecosystems: The Case of Digital Payments [PDF]

, 2014
In digital ecosystems, the fusion relation between business and technology means that the decision of technical compatibility of the offering is also the decision of how to position the firm relative to the coopetive relations that characterize business ecosystems.
Henningsson, Stefan, Hedman, Jonas
openaire   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Analysis of the current status and future vision of innovation in a tertiary hospital in Catalonia: a cross-sectional study

BMC Health Services Research
Background Innovation in healthcare is a complex process involving the creation or modification of products, services, or processes, and their successful implementation in clinical settings. University Hospital Germans Trias i Pujol (HUGTP) implemented a
Mireia Cano, Eloi Querol Carranza, Gerard Albreda, Laura Ricou, Oriol Estrada, Daniel Moreno-Martinez   +5 more
doaj   +1 more source

Leading in the Digital Age: The Role of Leadership in Organizational Digital Transformation

Administrative Sciences
In the modern digital age, organizations face unprecedented challenges and possibilities while managing the intricacies of digital transformation. Accelerated technological developments, changing customer preferences, heightened competition, and dynamic ...
António Sacavém, Andréia de Bem Machado, J. R. dos Santos, Ana Palma-Moreira, Helena Belchior-Rocha, M. Au-Yong-Oliveira   +5 more
semanticscholar   +1 more source

The Interplay of Digital Transformational Leadership, Organizational Agility, and Digital Transformation

Journal of the Knowledge Economy, 2023
The rules of the game are changing in organizations due to several digital advances, ecosystems, industries, and fields. Also, the emergence of new institutional infrastructures and complex systems during this period can result in digital transformation (DT).
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Applying Decision Transformers to Enhance Neural Local Search on the Job Shop Scheduling Problem

AI
Background: The job shop scheduling problem (JSSP) and its solution algorithms have been of enduring interest in both academia and industry for decades.
Constantin Waubert de Puiseau, Fabian Wolz, Merlin Montag, Jannik Peters, Hasan Tercan, Tobias Meisen   +5 more
doaj   +1 more source

The Role of Organizational Culture in Digital Transformation and Modern Accounting Practices Among Jordanian SMEs

Journal of Risk and Financial Management
This study investigates the impact of digital transformation on modern accounting practices among Jordanian SMEs, focusing on the moderating role of organizational culture.
Elina F. Hasan, Mohammad Abdalkarim Alzuod, Khalid Hasan Al Jasimee, Sajead Mowafaq Alshdaifat, Areej Hijazin, Laith T. Khrais   +5 more
semanticscholar   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source