Results 61 to 70 of about 1,473,665 (331)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Analysis of the current status and future vision of innovation in a tertiary hospital in Catalonia: a cross-sectional study

BMC Health Services Research
Background Innovation in healthcare is a complex process involving the creation or modification of products, services, or processes, and their successful implementation in clinical settings. University Hospital Germans Trias i Pujol (HUGTP) implemented a
Mireia Cano, Eloi Querol Carranza, Gerard Albreda, Laura Ricou, Oriol Estrada, Daniel Moreno-Martinez   +5 more
doaj   +1 more source

Applying Decision Transformers to Enhance Neural Local Search on the Job Shop Scheduling Problem

AI
Background: The job shop scheduling problem (JSSP) and its solution algorithms have been of enduring interest in both academia and industry for decades.
Constantin Waubert de Puiseau, Fabian Wolz, Merlin Montag, Jannik Peters, Hasan Tercan, Tobias Meisen   +5 more
doaj   +1 more source

Business school techspectations Technology in the daily lives and educational experiences of business students [PDF]

, 2010
Business School Techspectations is the second in a series of reports based on research by the DCU Leadership, Innovation and Knowledge Research Centre (LInK) at DCU Business School.
Alexopoulos, Angelos, Lynn, Theo
core  

Seven Dimensions of Portability for Language Documentation and Description

, 2002
The process of documenting and describing the world's languages is undergoing radical transformation with the rapid uptake of new digital technologies for capture, storage, annotation and dissemination.
Bird, Steven, Simons, Gary
core   +6 more sources

Automatic generation of audio content for open learning resources [PDF]

, 2009
This paper describes how digital talking books (DTBs) with embedded functionality for learners can be generated from content structured according to the OU OpenLearn schema.
Brasher, Andrew, McAndrew, Patrick
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Business Process Redesign in the Perioperative Process: A Case Perspective for Digital Transformation [PDF]

, 2019
This case study investigates business process redesign within the perioperative process as a method to achieve digital transformation. Specific perioperative sub-processes are targeted for re-design and digitalization, which yield improvement. Based on a
Daily, Sandra, Doster, Barbara, Lewis, Carmen, Ryan, Jim   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Transforming document management for environmental sustainability: the mediating effect of pro-environmental culture and service satisfaction in higher education institutions

Frontiers in Sustainability
This research investigates the factors influencing environmental sustainability in a Peruvian higher education institution (HEI), using Structural Equation Modeling (SEM) with SmartPLS.
Jessie Bravo, Carlos Valdivia, Roger Alarcón, Nilton Germán, Oscar Serquén, Janet Aquino, Marco Agustín Arbulú Ballesteros, Laurita Guevara   +7 more
doaj   +1 more source